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5daf

Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64063

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Kelch-like ECH-associated protein 1

Homo sapiens

UniProt Q14145

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 (5aS,6S,9aS)-7-hydroxy-2,6,9a-trimethyl-3-(pyridin-3-yl)-4,5,5a,6,9,9a-hexahydro-2H-benzo[g]indazole-8-carbonitrile × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1u6d 1zgk 3vng 3vnh 3zgc 4cxi 4ifj 4ifn 4in4 4in4 4in4 4iqk

105 assemblies; showing the first 12

Homodimer
3zgd 4cxj 4cxt 4l7b 5dad 5daf 6ffm 6rog 6w67 6w68 6w69 7exi

35 assemblies; showing the first 12

Homotetramer

None

Other homooligomers
4l7c 4l7d 4n1b

3 assemblies

Heteromeric or nucleic-acid complex
3zgc 4ifl 4ifl 5f72 5f72 5nlb 5wfv 5wg1 5x54 5x54 6fmp 6fmq

52 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name KEAP1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–140； UniProt 49–182

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5daf
Deposition date deposition_date2015-08-19
Structure title titleCrystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64063
Keywords keywordsKEAP1, Trascription Regulation, BTB domain, Cysteine Modification, C1-(R)-Cys151 adduct, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5daf__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5daf__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5daf__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.02 Å
Rg (electron density)20.32 Å
Total Rg21.14 Å
Atom count1934
Residues242
Excluded volume34884 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5daf__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd5dafa_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.42 — POZ domain
Superfamily Superfamily superfamilyd.42.1 — POZ domain
Family Family familyd.42.1.0 — automated matches

CATH v4.4 (1 domains)

Domain ID domain_id5dafA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
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7. Citations (1)