7tql

CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Eukaryotic translation initiation factor 5B

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	IF2P_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 1； PDBConstruct 1–619； UniProt 602–1219

40S ribosomal protein S2

Homo sapiens

UniProt P15880

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS2_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain D； PDBConstruct 1–218； UniProt 59–276

40S ribosomal protein S4, X isoform

Homo sapiens

UniProt P62701

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS4X_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain E； PDBConstruct 1–258； UniProt 2–259

40S ribosomal protein S3

Homo sapiens

UniProt P23396

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS3_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain F； PDBConstruct 1–225； UniProt 3–227

40S ribosomal protein S6

Homo sapiens

UniProt P62753

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS6_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain G； PDBConstruct 1–226； UniProt 1–226

40S ribosomal protein S7

Homo sapiens

UniProt P62081

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS7_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain H； PDBConstruct 1–185； UniProt 8–192

40S ribosomal protein S8

Homo sapiens

UniProt P62241

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS8_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain I； PDBConstruct 1–205； UniProt 2–206

40S ribosomal protein S9

Homo sapiens

UniProt P46781

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS9_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain J； PDBConstruct 1–180； UniProt 2–181

40S ribosomal protein S5

Homo sapiens

UniProt P46782

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS5_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain K； PDBConstruct 1–189； UniProt 16–204

40S ribosomal protein S11

Homo sapiens

UniProt P62280

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS11_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain L； PDBConstruct 1–147； UniProt 2–148

40S ribosomal protein S10

Homo sapiens

UniProt A0A2R8Y7H1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A2R8Y7H1_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain M； PDBConstruct 1–97； UniProt 1–97

40S ribosomal protein S15

Homo sapiens

UniProt P62841

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS15_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain Q； PDBConstruct 1–115； UniProt 15–129

40S ribosomal protein S16

Homo sapiens

UniProt P62249

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS16_HUMAN
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain R； PDBConstruct 1–139； UniProt 8–146

40S ribosomal protein S19

Homo sapiens

UniProt P39019

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS19_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain U； PDBConstruct 1–139； UniProt 4–142

40S ribosomal protein S15a

Homo sapiens

UniProt P62244

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS15A_HUMAN
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain W； PDBConstruct 1–129； UniProt 2–130

40S ribosomal protein S23

Homo sapiens

UniProt P62266

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS23_HUMAN
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain X； PDBConstruct 1–141； UniProt 2–142

Isoform 3 of 40S ribosomal protein S24

Homo sapiens

UniProt P62847

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS24_HUMAN
Isoform	P62847-3
PDB entities	27
Chains and sequence ranges	Author chain Y； PDBConstruct 1–123； UniProt 4–126

40S ribosomal protein S21

Homo sapiens

UniProt P63220

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS21_HUMAN
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain Z； PDBConstruct 1–82； UniProt 1–82

40S ribosomal protein S27

Homo sapiens

UniProt P42677

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS27_HUMAN
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain b； PDBConstruct 1–82； UniProt 2–83

40S ribosomal protein S26

Homo sapiens

UniProt P62854

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS26_HUMAN
Isoform	—
PDB entities	31
Chains and sequence ranges	Author chain c； PDBConstruct 1–99； UniProt 2–100

40S ribosomal protein S27a

Homo sapiens

UniProt P62979

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 ribosomal protein eL41 × 1 Receptor of activated protein C kinase 1 × 1 （P63244） PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS27A_HUMAN
Isoform	—
PDB entities	35
Chains and sequence ranges	Author chain g； PDBConstruct 1–65； UniProt 85–149

Receptor of activated protein C kinase 1

Homo sapiens

UniProt P63244

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 36 RNA 2	Eukaryotic translation initiation factor 5B × 1 （O60841） 18S ribosomal RNA × 1 Human Met-tRNAiMet × 1 Translation initiation factor eIF1A × 1 ribosomal protein uS2 × 2 40S ribosomal protein S2 × 1 （P15880） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S8 × 1 （P62241） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S10 × 1 （A0A2R8Y7H1） ribosomal protein uS15 × 1 ribosomal protein eS12 × 1 ribosomal protein uS11 × 1 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） ribosomal protein eS17 × 1 ribosomal protein uS13 × 1 40S ribosomal protein S19 × 1 （P39019） ribosomal protein uS10 × 1 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S23 × 1 （P62266） Isoform 3 of 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S21 × 1 （P63220） ribosomal protein eS25 × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S26 × 1 （P62854） ribosomal protein eS28 × 1 ribosomal protein eS30 × 1 ribosomal protein uS14 × 1 40S ribosomal protein S27a × 1 （P62979） ribosomal protein eL41 × 1 PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 GUANOSINE-5'-MONOPHOSPHATE × 1 ZINC ION × 3	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RACK1_HUMAN
Isoform	—
PDB entities	37
Chains and sequence ranges	Author chain j； PDBConstruct 1–314； UniProt 2–315

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7tql
Deposition date deposition_date	2022-01-26
Structure title title	CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.
Keywords keywords	eIF5B, translation, initiation, eIF1A, RIBOSOME; RIBOSOME
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7tql__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7tql__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

7tql__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	73.96 Å
Rg (electron density)	75.41 Å
Total Rg	75.32 Å
Atom count	80976
Residues	7239
Excluded volume	1313000 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`7tql__assembly_1__model_1`	38-meric （38）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (40)

Entity 1 Entity 1 polymer

Description description	Eukaryotic translation initiation factor 5B
Molecular weight formula_weight	69868.1 kDa
EC 编号 ec_number	3.6.5.3
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1
Atom count atom_count	80976

EERAYDKAKRRIEKRRLEHSKNVTEKDKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLTPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEI

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 2 Entity 2 polymer

Description description	18S ribosomal RNA
Molecular weight formula_weight	534544.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	2

UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUAAGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUUUGGUCGCUCGUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCGACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGUGGUGACUCUAGAUAACCUCGGGCCGAUCGCACGCCGGCGGCGACGACCCAUUCGAACGUCUGCCCUAUCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCGCGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCUUUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAGGGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUCGUAGUUGGAUCUCUAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCGCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUUCGGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACCAUAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCCGGGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGAAUUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAACCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGUGGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCGGUCGGCGUAACUUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUCCUACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCCCUCGGAUCGGCCCCGCCGGGGUGCCCUGGCGGAGCGCUGAGAAGACGGUCGAACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGGAUCAUUA

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 3 Entity 3 polymer

Description description	Human Met-tRNAiMet
Molecular weight formula_weight	24231.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	3

AGCAGAGUGGCGCAGCGGAAGCGUGCUGGGCCCAUAACCCAGAGGUCGAUGGAUCGAAACCAUCCUCUGCUACCA

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 4 Entity 4 polymer

Description description	Translation initiation factor eIF1A
Molecular weight formula_weight	10384.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

RELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHA

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 5 Entity 5 polymer

Description description	ribosomal protein uS2
Molecular weight formula_weight	47843.6 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,C

SGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHG

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 6 Entity 6 polymer

Description description	40S ribosomal protein S2
Molecular weight formula_weight	24091.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

EWMPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKT

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 7 Entity 7 polymer

Description description	40S ribosomal protein S4, X isoform
Molecular weight formula_weight	29164.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

ARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 8 Entity 8 polymer

Description description	40S ribosomal protein S3
Molecular weight formula_weight	24970.3 kDa
EC 编号 ec_number	4.2.99.18
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

VQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 9 Entity 9 polymer

Description description	40S ribosomal protein S6
Molecular weight formula_weight	26157.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQE

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 10 Entity 10 polymer

Description description	40S ribosomal protein S7
Molecular weight formula_weight	21187.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

IVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 11 Entity 11 polymer

Description description	40S ribosomal protein S8
Molecular weight formula_weight	23946.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 12 Entity 12 polymer

Description description	40S ribosomal protein S9
Molecular weight formula_weight	21279.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

PVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 13 Entity 13 polymer

Description description	40S ribosomal protein S5
Molecular weight formula_weight	21327.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

DIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 14 Entity 14 polymer

Description description	40S ribosomal protein S11
Molecular weight formula_weight	17170.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

ADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKA

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 15 Entity 15 polymer

Description description	40S ribosomal protein S10
Molecular weight formula_weight	11616.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 16 Entity 16 polymer

Description description	ribosomal protein uS15
Molecular weight formula_weight	16340.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

GRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYE

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 17 Entity 17 polymer

Description description	ribosomal protein eS12
Molecular weight formula_weight	13347.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

GVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFK

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 18 Entity 18 polymer

Description description	ribosomal protein uS11
Molecular weight formula_weight	14344.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

GPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 19 Entity 19 polymer

Description description	40S ribosomal protein S15
Molecular weight formula_weight	13586.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

FTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 20 Entity 20 polymer

Description description	40S ribosomal protein S16
Molecular weight formula_weight	15765.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

QSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 21 Entity 21 polymer

Description description	ribosomal protein eS17
Molecular weight formula_weight	15250.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S

GRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRG

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 22 Entity 22 polymer

Description description	ribosomal protein uS13
Molecular weight formula_weight	16496.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

LVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRR

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 23 Entity 23 polymer

Description description	40S ribosomal protein S19
Molecular weight formula_weight	15409.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

VTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAAN

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 24 Entity 24 polymer

Description description	ribosomal protein uS10
Molecular weight formula_weight	11508.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIA

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 25 Entity 25 polymer

Description description	40S ribosomal protein S15a
Molecular weight formula_weight	14734.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

VRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 26 Entity 26 polymer

Description description	40S ribosomal protein S23
Molecular weight formula_weight	15626.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

GKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 27 Entity 27 polymer

Description description	Isoform 3 of 40S ribosomal protein S24
Molecular weight formula_weight	14361.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y

TVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 28 Entity 28 polymer

Description description	40S ribosomal protein S21
Molecular weight formula_weight	8977.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIRRMGESDDSILRLAKADGIVSKN

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 29 Entity 29 polymer

Description description	ribosomal protein eS25
Molecular weight formula_weight	8182.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a

DKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNT

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 30 Entity 30 polymer

Description description	40S ribosomal protein S27
Molecular weight formula_weight	9210.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b

PLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 31 Entity 31 polymer

Description description	40S ribosomal protein S26
Molecular weight formula_weight	11341.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c

TKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNIVEAAAVRDISEASVFDAYVLPKLYVKLHYCVSCAIHSKVVRNRSREARKDRTPPPR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 32 Entity 32 polymer

Description description	ribosomal protein eS28
Molecular weight formula_weight	6451.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

PIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREA

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 33 Entity 33 polymer

Description description	ribosomal protein eS30
Molecular weight formula_weight	5640.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e

AAAAAARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVKGPNANS

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 34 Entity 34 polymer

Description description	ribosomal protein uS14
Molecular weight formula_weight	6502.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f

HQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 35 Entity 35 polymer

Description description	40S ribosomal protein S27a
Molecular weight formula_weight	7623.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	g

YTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYC

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 36 Entity 36 polymer

Description description	ribosomal protein eL41
Molecular weight formula_weight	2683.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	h

MRAKWRKKRMRRLKRKRRK

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 37 Entity 37 polymer

Description description	Receptor of activated protein C kinase 1
Molecular weight formula_weight	34726.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	j

TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 38 Entity 38 non-polymer

Description description	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Molecular weight formula_weight	522.2 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 39 Entity 39 non-polymer

Description description	GUANOSINE-5'-MONOPHOSPHATE
Molecular weight formula_weight	363.2 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 40 Entity 40 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	3

▼

6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id	7tql101
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	300 — P-loop containing nucleotide triphosphate hydrolases

Domain ID domain_id	7tql102
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	10050 — Translation initiation factor IF- 2, domain 3

Domain ID domain_id	7tql103
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	10 — Translation factors

Domain ID domain_id	7tqlD01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	160 — Double Stranded RNA Binding Domain
Homologous superfamily homologous superfamily	20 —

Domain ID domain_id	7tqlF01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	300 — GMP Synthetase; Chain A, domain 3
Homologous superfamily homologous superfamily	20 — K homology (KH) domain

Domain ID domain_id	7tqlQ01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	860 — 30s Ribosomal Protein S19; Chain A
Homologous superfamily homologous superfamily	10 — Ribosomal protein S19/S15

Domain ID domain_id	7tqlT01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily	50 —

Domain ID domain_id	7tqla01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.200 Å
Low-resolution limit resolution_low	237.110 Å
R factor r_factor	0.2818
R_work r_work	0.2818
R_free r_free	—

Resolution resolution	3.20 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	190000

CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.

1. Protein Identity and Related Structures Protein Identity & Related Structures

Eukaryotic translation initiation factor 5B

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S4, X isoform

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S9

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S11

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer