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7x47

Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 2E6 (classified from CVB1 mature virion in complex with 8A10 and 2E6)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Virion protein 1

OrganismNot specified

UniProt W8GTF7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 300 2E6 light chain × 60 2E6 heavy chain × 60 VP2 × 60 （A0A2S0RQC2） Genome polyprotein × 60 （A0A0G4PYT0） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 2E6 light chain × 1 2E6 heavy chain × 1 VP2 × 1 （A0A2S0RQC2） Genome polyprotein × 1 （A0A0G4PYT0） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 25 2E6 light chain × 5 2E6 heavy chain × 5 VP2 × 5 （A0A2S0RQC2） Genome polyprotein × 5 （A0A0G4PYT0） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 30 2E6 light chain × 6 2E6 heavy chain × 6 VP2 × 6 （A0A2S0RQC2） Genome polyprotein × 6 （A0A0G4PYT0） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 5 2E6 light chain × 1 2E6 heavy chain × 1 VP2 × 1 （A0A2S0RQC2） Genome polyprotein × 1 （A0A0G4PYT0） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7dpf 7dpf 7dpf 7dpf 7dpf 7dpg 7dpg 7dpg 7dpg 7dpg 7dpz 7dpz

130 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name W8GTF7_9ENTO
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–278； UniProt 1–278

VP2

OrganismNot specified

UniProt A0A2S0RQC2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 300 2E6 light chain × 60 2E6 heavy chain × 60 Virion protein 1 × 60 （W8GTF7） Genome polyprotein × 60 （A0A0G4PYT0） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 2E6 light chain × 1 2E6 heavy chain × 1 Virion protein 1 × 1 （W8GTF7） Genome polyprotein × 1 （A0A0G4PYT0） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 25 2E6 light chain × 5 2E6 heavy chain × 5 Virion protein 1 × 5 （W8GTF7） Genome polyprotein × 5 （A0A0G4PYT0） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 30 2E6 light chain × 6 2E6 heavy chain × 6 Virion protein 1 × 6 （W8GTF7） Genome polyprotein × 6 （A0A0G4PYT0） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 5 2E6 light chain × 1 2E6 heavy chain × 1 Virion protein 1 × 1 （W8GTF7） Genome polyprotein × 1 （A0A0G4PYT0） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7dpf 7dpf 7dpf 7dpf 7dpf 7dpg 7dpg 7dpg 7dpg 7dpg 7dpz 7dpz

120 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name A0A2S0RQC2_9ENTO
Isoform —
PDB entities 4
Chains and sequence ranges Author chain B； PDBConstruct 1–263； UniProt 70–332

Genome polyprotein

OrganismNot specified

UniProt A0A0G4PYT0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 300 2E6 light chain × 60 2E6 heavy chain × 60 Virion protein 1 × 60 （W8GTF7） VP2 × 60 （A0A2S0RQC2） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 2E6 light chain × 1 2E6 heavy chain × 1 Virion protein 1 × 1 （W8GTF7） VP2 × 1 （A0A2S0RQC2） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 25 2E6 light chain × 5 2E6 heavy chain × 5 Virion protein 1 × 5 （W8GTF7） VP2 × 5 （A0A2S0RQC2） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 30 2E6 light chain × 6 2E6 heavy chain × 6 Virion protein 1 × 6 （W8GTF7） VP2 × 6 （A0A2S0RQC2） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 5 2E6 light chain × 1 2E6 heavy chain × 1 Virion protein 1 × 1 （W8GTF7） VP2 × 1 （A0A2S0RQC2） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7dpf 7dpf 7dpf 7dpf 7dpf 7x47 7x47 7x47 7x47 7x47

10 assemblies

View Construct and Data Evidence
UniProt name A0A0G4PYT0_9ENTO
Isoform —
PDB entities 5
Chains and sequence ranges Author chain C； PDBConstruct 1–238； UniProt 333–570

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7x47
Deposition date deposition_date2022-03-02
Structure title titleCryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 2E6 (classified from CVB1 mature virion in complex with 8A10 and 2E6)
Keywords keywordsCoxsackievirus B1, Neutralizing antibody, Cryo-EM, VIRUS; VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7x47__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7x47__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7x47__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）0.00 Å
Rg (electron density)151.40 Å
Total Rg151.30 Å
Atom count410040
Residues52680
Excluded volume7287700 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7x47__assembly_1__model_1 300-meric （300） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7x47__assembly_2__model_1 pentameric （5） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 7x47__assembly_3__model_1 25-meric （25） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 7x47__assembly_4__model_1 30-meric （30） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 7x47__assembly_5__model_1 pentameric （5） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 3 domains

CATH v4.4 (3 domains)

Domain ID domain_id7x47B01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily20 —
Domain ID domain_id7x47H01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id7x47L01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
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7. Citations (1)