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7zm0

Structure of UCHL1 in complex with GK13S inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Ubiquitin carboxyl-terminal hydrolase isozyme L1

Homo sapiens

UniProt P09936

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
10 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
4 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
5 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
6 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
7 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
8 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count
9 Protein monomer Monomer Protein 1 (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2etl 2etl 2len 3irt 3irt 4jkj 4jkj 7zm0 7zm0 7zm0 7zm0 7zm0

31 assemblies; showing the first 12

Homodimer
8xi7

1 assemblies

Homotetramer
2etl 2etl 4jkj 4jkj

4 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
3ifw 3kvf 3kw5 4dm9 4dm9 9o4m 9o4m

7 assemblies

View Construct and Data Evidence
UniProt name UCHL1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–227； UniProt 1–223 Author chain B； PDBConstruct 5–227； UniProt 1–223 Author chain C； PDBConstruct 5–227； UniProt 1–223 Author chain D； PDBConstruct 5–227； UniProt 1–223 Author chain E； PDBConstruct 5–227； UniProt 1–223 Author chain F； PDBConstruct 5–227； UniProt 1–223 Author chain G； PDBConstruct 5–227； UniProt 1–223 Author chain H； PDBConstruct 5–227； UniProt 1–223 Author chain I； PDBConstruct 5–227； UniProt 1–223 Author chain J； PDBConstruct 5–227； UniProt 1–223

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7zm0
Deposition date deposition_date2022-04-18
Structure title titleStructure of UCHL1 in complex with GK13S inhibitor
Keywords keywordsDUB, UCHL1, UCH-L1, UCHL-1, deubiquitinase, ubiquitin, cyanopyrrolidine, inhibitor, HYDROLASE; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7zm0__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7zm0__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7zm0__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.43 Å
Rg (electron density)16.03 Å
Total Rg17.13 Å
Atom count1644
Residues213
Excluded volume29213 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7zm0__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7zm0__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 7zm0__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 7zm0__assembly_4__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 7zm0__assembly_5__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 7zm0__assembly_6__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 7zm0__assembly_7__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 7zm0__assembly_8__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
9 1 7zm0__assembly_9__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
10 1 7zm0__assembly_10__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)