8bwf

PTBP1 RRM1 bound to an allosteric inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Polypyrimidine tract-binding protein 1

Homo sapiens

UniProt P26599

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 5 AMINO GROUP × 1 Consistent with protein count
10 Protein heterocomplex Heteromer Protein 2 Ligand × 1 AMINO GROUP × 1 Consistent with protein count
11 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 2 AMINO GROUP × 1 Consistent with protein count
12 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 1 AMINO GROUP × 1 Consistent with protein count
13 Protein heterocomplex Heteromer Protein 2 Ligand × 1 AMINO GROUP × 1 Consistent with protein count
14 Protein heterocomplex Heteromer Protein 2 Ligand × 1 AMINO GROUP × 1 Consistent with protein count
15 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 1 AMINO GROUP × 1 Consistent with protein count
16 Protein heterocomplex Heteromer Protein 2 Ligand × 1 AMINO GROUP × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Ligand × 1 AMINO GROUP × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 1 AMINO GROUP × 1 GLYCEROL × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 2 AMINO GROUP × 1 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Ligand × 1 AMINO GROUP × 1 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 2 AMINO GROUP × 1 GLYCEROL × 1 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 3 AMINO GROUP × 1 Consistent with protein count
8 Protein heterocomplex Heteromer Protein 2 Ligand × 1 SULFATE ION × 1 AMINO GROUP × 1 Consistent with protein count
9 Protein heterocomplex Heteromer Protein 2 Ligand × 1 AMINO GROUP × 1 GLYCEROL × 2 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name PTBP1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 3–86; UniProt 57–140 Author chain B; PDBConstruct 3–86; UniProt 57–140 Author chain C; PDBConstruct 3–86; UniProt 57–140 Author chain D; PDBConstruct 3–86; UniProt 57–140 Author chain E; PDBConstruct 3–86; UniProt 57–140 Author chain F; PDBConstruct 3–86; UniProt 57–140 Author chain G; PDBConstruct 3–86; UniProt 57–140 Author chain H; PDBConstruct 3–86; UniProt 57–140 Author chain I; PDBConstruct 3–86; UniProt 57–140 Author chain J; PDBConstruct 3–86; UniProt 57–140 Author chain K; PDBConstruct 3–86; UniProt 57–140 Author chain L; PDBConstruct 3–86; UniProt 57–140 Author chain M; PDBConstruct 3–86; UniProt 57–140 Author chain N; PDBConstruct 3–86; UniProt 57–140 Author chain O; PDBConstruct 3–86; UniProt 57–140 Author chain P; PDBConstruct 3–86; UniProt 57–140

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8bwf
Deposition date deposition_date2022-12-06
Structure title titlePTBP1 RRM1 bound to an allosteric inhibitor
Keywords keywordsRNA binding, protein-peptide interaction, inhibitor, RNA BINDING PROTEIN; RNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8bwf__assembly_11__model_1

Assembly 11 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8bwf__assembly_11__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8bwf__assembly_11__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)13.98 Å
Rg (electron density)12.59 Å
Total Rg14.04 Å
Atom count776
Residues93
Excluded volume14042 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8bwf__assembly_1__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8bwf__assembly_2__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 8bwf__assembly_3__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 8bwf__assembly_4__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 8bwf__assembly_5__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 8bwf__assembly_6__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 8bwf__assembly_7__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 8bwf__assembly_8__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
9 1 8bwf__assembly_9__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
10 1 8bwf__assembly_10__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
11 1 8bwf__assembly_11__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
12 1 8bwf__assembly_12__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
13 1 8bwf__assembly_13__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
14 1 8bwf__assembly_14__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
15 1 8bwf__assembly_15__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
16 1 8bwf__assembly_16__model_1 dimeric (2) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)