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8ccw

Crystal structure of human Sirt3 in complex with an acetylated HIV1 Tat-46-54 substrate peptide

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Homo sapiens

UniProt Q9NTG7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Protein Tat × 1 （P12506） ZINC ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3gls 3gls 3gls 3gls 3gls 3gls 4bn4 4bn5 4bn5 4bn5 4bn5 4bn5

38 assemblies; showing the first 12

Homodimer
9ktk 9ktk

2 assemblies

Homotetramer
9ktk

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
3glr 3glt 3glu 4bve 4bvf 4bvg 4c78 4c7b 4fvt 4fz3 4hd8 5bwn

50 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SIR3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–282； UniProt 118–399

Protein Tat

OrganismNot specified

UniProt P12506

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 NAD-dependent protein deacetylase sirtuin-3, mitochondrial × 1 （Q9NTG7） ZINC ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1tac 1tbc 1tiv

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2bgn 2bgn 2bgr 8ccw 8ccz 8ccz

6 assemblies

View Construct and Data Evidence
UniProt name TAT_HV1Z2
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–9； UniProt 46–54

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8ccw
Deposition date deposition_date2023-01-27
Structure title titleCrystal structure of human Sirt3 in complex with an acetylated HIV1 Tat-46-54 substrate peptide
Keywords keywordsSirtuin, substrate, HIV, Tat, complex, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8ccw__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8ccw__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8ccw__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.68 Å
Rg (electron density)19.41 Å
Total Rg20.43 Å
Atom count2234
Residues282
Excluded volume40091 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8ccw__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)