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8f4v

Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Neuronal acetylcholine receptor subunit alpha-7

Homo sapiens

UniProt P36544

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 5 ;(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside ; × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2maw

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
7rpm 8f4v

2 assemblies

Heteromeric or nucleic-acid complex
7eki 7ekp 7ekt 7koo 7koq 7kox 8c9x 8cau 8ce4 8ci1 8ci2 8p1h

42 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ACHA7_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–272； UniProt 231–496 Author chain B； PDBConstruct 7–272； UniProt 231–496 Author chain C； PDBConstruct 7–272； UniProt 231–496 Author chain D； PDBConstruct 7–272； UniProt 231–496 Author chain E； PDBConstruct 7–272； UniProt 231–496

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8f4v
Deposition date deposition_date2022-11-11
Structure title titleAlpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state
Keywords keywordsnicotinic acetylcholine receptor, transmembrane and intracellular domain, desensitized state, ivermectin, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8f4v__assembly_1__model_6

Assembly 1 · Model 6 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8f4v__assembly_1__model_6 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8f4v__assembly_1__model_6 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）38.80 Å
Rg (electron density)37.76 Å
Total Rg38.37 Å
Atom count21090
Residues1320
Excluded volume189180 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8f4v__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 8f4v__assembly_1__model_2 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 8f4v__assembly_1__model_3 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 8f4v__assembly_1__model_4 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 8f4v__assembly_1__model_5 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 8f4v__assembly_1__model_6 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 8f4v__assembly_1__model_7 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 8f4v__assembly_1__model_8 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 8f4v__assembly_1__model_9 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 8f4v__assembly_1__model_10 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 8f4v__assembly_1__model_11 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 8f4v__assembly_1__model_12 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 8f4v__assembly_1__model_13 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 8f4v__assembly_1__model_14 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 8f4v__assembly_1__model_15 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)