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8fay

Human MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Adenine DNA glycosylase

Homo sapiens

UniProt Q9UIF7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Monomer Protein 1 DNA 2 ;DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3') ; × 1 ;DNA (5'-D(P*GP*TP*CP*CP*AP*(NRI)P*GP*TP*CP*T)-3') ; × 1 IRON/SULFUR CLUSTER × 1 SULFATE ION × 7 water × 3 Consistent with all polymers
2 Protein–DNA Monomer Protein 1 DNA 2 ;DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3') ; × 1 ;DNA (5'-D(P*GP*TP*CP*CP*AP*(NRI)P*GP*TP*CP*T)-3') ; × 1 IRON/SULFUR CLUSTER × 1 SULFATE ION × 6 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1x51 3n5n 3n5n

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8fay 8fay

2 assemblies

View Construct and Data Evidence
UniProt name MUTYH_HUMAN
Isoform Q9UIF7-6
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–459； UniProt 39–491 Author chain D； PDBConstruct 7–459； UniProt 39–491

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8fay
Deposition date deposition_date2022-11-29
Structure title titleHuman MUTYH adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)
Keywords keywordsProtein-DNA complex, DNA repair, Base Excision Repair, HYDROLASE, HYDROLASE-DNA complex; HYDROLASE/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8fay__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8fay__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8fay__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.59 Å
Rg (electron density)24.53 Å
Total Rg25.20 Å
Atom count6716
Residues413
Excluded volume60537 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8fay__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8fay__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)