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8g6o

HIV-1 capsid lattice bound to IP6 and Lenacapavir

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Capsid protein

Human immunodeficiency virus 1

UniProt B6DRA0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 25 No other associated polymer Consistent with protein count
2 Protein homooligomer Homooligomer Protein 5 No other associated polymer Consistent with protein count
3 Protein homooligomer Homooligomer Protein 5 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7urt 7urt 8eep 8eep 8eet 8eet

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
5mcx 5mcy 5up4 5w4o 5w4p 5w4q 6axr 6axs 6axt 6axv 6axw 6axx

88 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
6ay9 6obh 6pu1 7n9u 7n9v 7n9x 8cky 8cl0 8cl1 8cl3

10 assemblies

View Construct and Data Evidence
UniProt name B6DRA0_9HIV1
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–232； UniProt 133–363 Author chain B； PDBConstruct 2–232； UniProt 133–363 Author chain C； PDBConstruct 2–232； UniProt 133–363 Author chain D； PDBConstruct 2–232； UniProt 133–363 Author chain E； PDBConstruct 2–232； UniProt 133–363

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8g6o
Deposition date deposition_date2023-02-15
Structure title titleHIV-1 capsid lattice bound to IP6 and Lenacapavir
Keywords keywordsHIV-1, capsid, lattice, virus, virus like particle; VIRUS LIKE PARTICLE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8g6o__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8g6o__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8g6o__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）67.43 Å
Rg (electron density)67.30 Å
Total Rg67.18 Å
Atom count65660
Residues4225
Excluded volume588580 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8g6o__assembly_1__model_1 25-meric （25） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8g6o__assembly_2__model_1 pentameric （5） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 8g6o__assembly_3__model_1 pentameric （5） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 7 domains

CATH v4.4 (7 domains)

Domain ID domain_id8g6oA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology375 — Human Immunodeficiency Virus Type 1 Capsid Protein
Homologous superfamily homologous superfamily10 — Human Immunodeficiency Virus Type 1 Capsid Protein
Domain ID domain_id8g6oA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1200 — Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A
Homologous superfamily homologous superfamily30 — Retrovirus capsid C-terminal domain
Domain ID domain_id8g6oB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology375 — Human Immunodeficiency Virus Type 1 Capsid Protein
Homologous superfamily homologous superfamily10 — Human Immunodeficiency Virus Type 1 Capsid Protein
Domain ID domain_id8g6oB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1200 — Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A
Homologous superfamily homologous superfamily30 — Retrovirus capsid C-terminal domain
Domain ID domain_id8g6oC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology375 — Human Immunodeficiency Virus Type 1 Capsid Protein
Homologous superfamily homologous superfamily10 — Human Immunodeficiency Virus Type 1 Capsid Protein
Domain ID domain_id8g6oD01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology375 — Human Immunodeficiency Virus Type 1 Capsid Protein
Homologous superfamily homologous superfamily10 — Human Immunodeficiency Virus Type 1 Capsid Protein
Domain ID domain_id8g6oD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology1200 — Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A
Homologous superfamily homologous superfamily30 — Retrovirus capsid C-terminal domain
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7. Citations (1)