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8i0k

Cryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase(E1) with TCAIM complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

2-oxoglutarate dehydrogenase complex component E1

Homo sapiens

UniProt Q02218

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 T-cell activation inhibitor, mitochondrial × 1 （Q8N3R3） MAGNESIUM ION × 2 THIAMINE DIPHOSPHATE × 1 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate × 1 CALCIUM ION × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
7wgr

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3ery 3ery 8i0k

3 assemblies

View Construct and Data Evidence
UniProt name ODO1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–911； UniProt 113–1023 Author chain B； PDBConstruct 1–911； UniProt 113–1023

T-cell activation inhibitor, mitochondrial

Homo sapiens

UniProt Q8N3R3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 2-oxoglutarate dehydrogenase complex component E1 × 2 （Q02218） MAGNESIUM ION × 2 THIAMINE DIPHOSPHATE × 1 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate × 1 CALCIUM ION × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8i0k

1 assemblies

View Construct and Data Evidence
UniProt name TCAIM_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–302； UniProt 188–489

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8i0k
Deposition date deposition_date2023-01-11
Structure title titleCryo-electron microscopic structure of the 2-oxoglutarate dehydrogenase(E1) with TCAIM complex
Keywords keywordsOGDH, proteostasis, DNAJC, PROTEIN BINDING; PROTEIN BINDING
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8i0k__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8i0k__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8i0k__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）38.76 Å
Rg (electron density)38.05 Å
Total Rg38.58 Å
Atom count16537
Residues2052
Excluded volume293900 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8i0k__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)