8i5c

Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

MHC class I antigen (Fragment)

Homo sapiens

UniProt U5YJJ6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
10 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
5 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
6 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
7 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
8 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
9 蛋白异源复合物 异源复合物 蛋白 5 Beta-2-microglobulin × 1 (P61769) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 U5YJJ6_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–274; UniProt 25–298 作者链 F; PDB构建体 1–274; UniProt 25–298 作者链 K; PDB构建体 1–274; UniProt 25–298 作者链 P; PDB构建体 1–274; UniProt 25–298 作者链 U; PDB构建体 1–274; UniProt 25–298 作者链 Z; PDB构建体 1–274; UniProt 25–298 作者链 e; PDB构建体 1–274; UniProt 25–298 作者链 j; PDB构建体 1–274; UniProt 25–298 作者链 o; PDB构建体 1–274; UniProt 25–298 作者链 t; PDB构建体 1–274; UniProt 25–298

Beta-2-microglobulin

Homo sapiens

UniProt P61769

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
10 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
5 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
6 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
7 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
8 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致
9 蛋白异源复合物 异源复合物 蛋白 5 MHC class I antigen (Fragment) × 1 (U5YJJ6) peptide KRAS-G12V-9 × 1 TCR alpha chain × 1 TCR beta chain × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 B2MG_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–99; UniProt 21–119 作者链 G; PDB构建体 1–99; UniProt 21–119 作者链 L; PDB构建体 1–99; UniProt 21–119 作者链 Q; PDB构建体 1–99; UniProt 21–119 作者链 V; PDB构建体 1–99; UniProt 21–119 作者链 a; PDB构建体 1–99; UniProt 21–119 作者链 f; PDB构建体 1–99; UniProt 21–119 作者链 k; PDB构建体 1–99; UniProt 21–119 作者链 p; PDB构建体 1–99; UniProt 21–119 作者链 u; PDB构建体 1–99; UniProt 21–119

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id8i5c
沉积日期 deposition_date2023-01-24
结构标题 titleCrystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)
关键词 keywordsKRAS, TCR, IMMUNE SYSTEM; IMMUNE SYSTEM
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

8i5c__assembly_7__model_1

Assembly 7 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

8i5c__assembly_7__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

8i5c__assembly_7__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)37.08 Å
Rg(电子密度)37.48 Å
总 Rg37.61 Å
原子数6574
残基数820
排除体积114890 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 8i5c__assembly_1__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 8i5c__assembly_2__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 8i5c__assembly_3__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 8i5c__assembly_4__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 1 8i5c__assembly_5__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 1 8i5c__assembly_6__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
7 1 8i5c__assembly_7__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
8 1 8i5c__assembly_8__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
9 1 8i5c__assembly_9__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
10 1 8i5c__assembly_10__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (5)

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6. 折叠分类 (SCOP + CATH) 40 domains

CATH v4.4 (40 domains)

结构域编号 domain_id8i5cA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5cA02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cB01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cD01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cF01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5cF02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cG01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cI01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cK01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5cK02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cL01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cN01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cP01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5cP02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cQ01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cS01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cU01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5cU02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cV01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cX01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cZ01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5cZ02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5ca01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cc01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5ce01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5ce02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cf01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5ch01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cj01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5cj02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5ck01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cm01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5co01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5co02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cp01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cr01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5ct01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id8i5ct02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cu01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id8i5cw01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
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7. 引用文献 (1)