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8iow

Cryo-EM structure of the sarilumab Fab/IL-6R complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Interleukin-6 receptor subunit alpha

Homo sapiens

UniProt P08887

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Light chain of Sarilumab Fab × 1 Heavy chain of Sarilumab Fab × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2arw

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1n26 1p9m 5fuc 5fuc 7dc8 7dc8 8d82 8iow 8j6f 8qy5 8qy6

11 assemblies

View Construct and Data Evidence
UniProt name IL6RA_HUMAN
Isoform P08887-2
PDB entities 1
Chains and sequence ranges Author chain D2； PDBConstruct 1–365； UniProt 1–365 Author chain I； PDBConstruct 1–365； UniProt 1–365

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8iow
Deposition date deposition_date2023-03-13
Structure title titleCryo-EM structure of the sarilumab Fab/IL-6R complex
Keywords keywordsantibody, IL-6R, structural protein, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8iow__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8iow__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8iow__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）28.93 Å
Rg (electron density)28.43 Å
Total Rg29.12 Å
Atom count4178
Residues537
Excluded volume73689 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8iow__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)