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8jjs

Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Isoform 2B of GTPase KRas

Homo sapiens

UniProt P01116

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 MAA-ILE-SAR-SAR-7T2-SAR-IAE-LEU-MEA-MLE-7TK × 1 GUANOSINE-5'-DIPHOSPHATE × 1 MAGNESIUM ION × 1 SULFATE ION × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
10jt 10jt 10nu 10nu 10nv 10nv 11qe 3gft 3gft 3gft 3gft 3gft

512 assemblies; showing the first 12

Homodimer
4lrw 4luc 4lv6 4pzy 5v6v 5whd 5whd 6bof 6m9w 6quv 6quw 6qux

22 assemblies; showing the first 12

Homotetramer
8stm

1 assemblies

Other homooligomers
4lyf 4lyh 5oco 5oct 6f76 6fa1 6gog 7acq

8 assemblies

Heteromeric or nucleic-acid complex
1d8d 1d8e 24hr 24hr 24hr 24hr 24hs 24hs 24hs 24hs 24hs 24hs

262 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RASK_HUMAN
Isoform P01116-2
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–179； UniProt 2–174

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8jjs
Deposition date deposition_date2023-05-31
Structure title titleHuman K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343
Keywords keywordsCYCLIC PEPTIDE, ONCOLOGY, SIGNALING PROTEIN-INHIBITOR COMPLEX; SIGNALING PROTEIN/INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8jjs__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8jjs__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8jjs__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.69 Å
Rg (electron density)15.36 Å
Total Rg16.45 Å
Atom count1487
Residues171
Excluded volume26243 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8jjs__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id8jjsA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)