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8r8d

Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Coagulation factor XII

Homo sapiens

UniProt P00748

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 6 其他Polymer 2 Garadacimab heavy chain variable region × 2 Garadacimab light chain variable region × 2 ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4bdw 4bdx 4xde 6x0s 6x0s 6x0s 6x0t 6x0t 6x0t 7prj

10 assemblies

Homodimer
7prk

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4xe4 6b74 6b77 6gt6 6l63 6l63 6qf7 6qf7 6szw 7fbp 8r8d

11 assemblies

View Construct and Data Evidence
UniProt name FA12_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–243； UniProt 373–615 Author chain B； PDBConstruct 1–243； UniProt 373–615

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8r8d
Deposition date deposition_date2023-11-29
Structure title titleCryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)
Keywords keywordsComplex, coagulation, trypsin-like serine protease, hereditary angioedema (HAE), BLOOD CLOTTING; BLOOD CLOTTING
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8r8d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8r8d__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8r8d__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.01 Å
Rg (electron density)30.33 Å
Total Rg31.08 Å
Atom count7044
Residues920
Excluded volume124700 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8r8d__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)