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8twx

Synthesis and Evaluation of Diaryl Ether Modulators of the Leukotriene A4 Hydrolase Aminopeptidase Activity

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Leukotriene A-4 hydrolase

Homo sapiens

UniProt P09960

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 5-[4-(4-chlorophenoxy)phenyl]-1H-pyrazol-3-amine × 1 ZINC ION × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 5-[4-(4-chlorophenoxy)phenyl]-1H-pyrazol-3-amine × 1 ZINC ION × 1 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 ZINC ION × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1gw6 1h19 1hs6 1sqm 2r59 3b7r 3b7u 3cho 3chp 3chq 3chr 3chs

82 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
5ni4

1 assemblies

Heteromeric or nucleic-acid complex
3b7s 3b7t 6enb

3 assemblies

View Construct and Data Evidence
UniProt name LKHA4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–607； UniProt 5–611 Author chain B； PDBConstruct 1–607； UniProt 5–611 Author chain C； PDBConstruct 1–607； UniProt 5–611

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8twx
Deposition date deposition_date2023-08-21
Structure title titleSynthesis and Evaluation of Diaryl Ether Modulators of the Leukotriene A4 Hydrolase Aminopeptidase Activity
Keywords keywordsLeukotriene A4 hydrolase, 4MDM, Aminipeptidase, Activator, HYDROLASE; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8twx__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8twx__assembly_3__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8twx__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.74 Å
Rg (electron density)24.75 Å
Total Rg25.63 Å
Atom count4845
Residues606
Excluded volume86686 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8twx__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8twx__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 8twx__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)