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8uwp

Crystal structure of SETDB1 Tudor domain in complex with MR46747

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone-lysine N-methyltransferase SETDB1

Homo sapiens

UniProt Q15047

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 (3S)-N-(4-chloro-3-{[2-(diethylamino)ethyl]carbamoyl}phenyl)-3-(diethylamino)pyrrolidine-1-carboxamide × 1 SULFATE ION × 2 1,2-ETHANEDIOL × 4 UNKNOWN ATOM OR ION × 2 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 (3S)-N-(4-chloro-3-{[2-(diethylamino)ethyl]carbamoyl}phenyl)-3-(diethylamino)pyrrolidine-1-carboxamide × 1 SULFATE ION × 4 1,2-ETHANEDIOL × 3 UNKNOWN ATOM OR ION × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3dlm 5kch 5kco 5ke2 5ke3 5kh6 5qt1 5qt2 6au2 6au3 7cjt 7cjt

19 assemblies; showing the first 12

Homodimer
7c9n 7caj 7cd9

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6bhd 6bhe 6bhg 6bhh 6bhi 6bpi 8iya 8iya 8iya

9 assemblies

View Construct and Data Evidence
UniProt name SETB1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 18–225； UniProt 196–403 Author chain B； PDBConstruct 18–225； UniProt 196–403

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8uwp
Deposition date deposition_date2023-11-07
Structure title titleCrystal structure of SETDB1 Tudor domain in complex with MR46747
Keywords keywordsSETDB1, epigenetics, methyllysine reader, SGC, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8uwp__assembly_1__model_1 monomeric （1） Excluded — —
Exclusion reason： The source record does not identify the atom or ion element unambiguously, so a reliable calculation is not possible.
2 1 8uwp__assembly_2__model_1 monomeric （1） Excluded — —
Exclusion reason： The source record does not identify the atom or ion element unambiguously, so a reliable calculation is not possible.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)