← Back to search
8w2t

Cryo-EM structure of human tankyrase 2 SAM-PARP filament - apo state (focused refinement map).

Method: ELECTRON MICROSCOPY
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Poly [ADP-ribose] polymerase tankyrase-2

Homo sapiens

UniProt Q9H2K2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3kr7 3kr8 3kr8 3mhj 3mhj 3mhk 3p0n 3p0n 3p0p 3p0p 3p0q 3p0q

221 assemblies; showing the first 12

Homodimer
3twq 4hki 4hki 4hkk 4hkk 4hkn 4hl5 4hlf 4hlf 4hlg 4hlg 4hlh

138 assemblies; showing the first 12

Homotetramer

None

Other homooligomers
8aly 8w2u

2 assemblies

Heteromeric or nucleic-acid complex
2y0i 3twr 3twr 3twr 3twr 3tws 3tws 3tws 3tws 3twt 3twt 3twt

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNKS2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain D； PDBConstruct 1–317； UniProt 850–1166 Author chain Q； PDBConstruct 1–317； UniProt 850–1166

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id8w2t
Deposition date deposition_date2024-02-21
Last revision last_revision2025-07-09
Structure title titleCryo-EM structure of human tankyrase 2 SAM-PARP filament - apo state (focused refinement map).
Keywords keywordsNAD+ ADP-ribosyltransferase, WNT signaling, inhibitor, SIGNALING PROTEIN, SIGNALING PROTEIN-INHIBITOR complex; SIGNALING PROTEIN/INHIBITOR
Experimental Method methodELECTRON MICROSCOPY
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8w2t__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8w2t__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8w2t__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.06 Å
Rg (electron density)30.66 Å
Total Rg31.33 Å
Atom count4488
Residues568
Excluded volume79399 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8w2t__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (2)

▶

7. Citations (1)