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8zd1

Cryo-EM structure of the xGPR4-Gs complex in pH6.2

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Homo sapiens

UniProt P63092

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 × 1 （P62873） Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 × 1 （P59768） G-protein coupled receptor 4 × 1 （A0A6I8PUB9） scFv16 × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6au6

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
25nv 25nx 5g53 5g53 5uz7 5vai 6b3j 6e3y 6e67 6e67 6eg8 6eg8

356 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GNAS2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 16–374； UniProt 26–394

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Homo sapiens

UniProt P62873

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short × 1 （P63092） Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 × 1 （P59768） G-protein coupled receptor 4 × 1 （A0A6I8PUB9） scFv16 × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
20yc 20zc 20zd 20zg 20zh 20zi 20zj 20zk 20zl 21ag 21du 23iv

1264 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GBB1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–338； UniProt 3–340

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Homo sapiens

UniProt P59768

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short × 1 （P63092） Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 × 1 （P62873） G-protein coupled receptor 4 × 1 （A0A6I8PUB9） scFv16 × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
20yc 20zc 20zd 20zg 20zh 20zi 20zj 20zk 20zl 21ag 21du 23iv

1237 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GBG2_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain G； PDBConstruct 1–52； UniProt 11–62

G-protein coupled receptor 4

Xenopus tropicalis

UniProt A0A6I8PUB9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short × 1 （P63092） Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 × 1 （P62873） Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 × 1 （P59768） scFv16 × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8zf4 8zf7 8zfb 9jvm

4 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8zd1 8zf6 8zfa

3 assemblies

View Construct and Data Evidence
UniProt name A0A6I8PUB9_XENTR
Isoform —
PDB entities 4
Chains and sequence ranges Author chain R； PDBConstruct 1–289； UniProt 13–301

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8zd1
Deposition date deposition_date2024-04-30
Structure title titleCryo-EM structure of the xGPR4-Gs complex in pH6.2
Keywords keywordspH6.2, xGPR4, Gs, MEMBRANE PROTEIN/IMMUNE SYSTEM, MEMBRANE PROTEIN, MEMBRANE PROTEIN-IMMUNE SYSTEM complex; MEMBRANE PROTEIN/IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8zd1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8zd1__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8zd1__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.14 Å
Rg (electron density)36.97 Å
Total Rg37.16 Å
Atom count8364
Residues1140
Excluded volume147780 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8zd1__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)