9ctv

Native human GABAA receptor of beta2-alpha1-gamma2-beta1-alpha2 assembly

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Gamma-aminobutyric acid receptor subunit beta-2

物种未注明

UniProt P47870

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 7 其他聚合物 6 Gamma-aminobutyric acid receptor subunit alpha-1 × 1 (P14867) Gamma-aminobutyric acid receptor subunit gamma-2 × 1 (P18507) Gamma-aminobutyric acid receptor subunit beta-1 × 1 (P18505) Gamma-aminobutyric acid receptor subunit alpha-2 × 1 (P47869) IgG2b Fab_1F4 Heavy Chain × 1 Kappa Fab_1F4 Light Chain × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 ;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate ; × 2 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 GBRB2_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–487; UniProt 26–512

Gamma-aminobutyric acid receptor subunit alpha-1

物种未注明

UniProt P14867

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 7 其他聚合物 6 Gamma-aminobutyric acid receptor subunit beta-2 × 1 (P47870) Gamma-aminobutyric acid receptor subunit gamma-2 × 1 (P18507) Gamma-aminobutyric acid receptor subunit beta-1 × 1 (P18505) Gamma-aminobutyric acid receptor subunit alpha-2 × 1 (P47869) IgG2b Fab_1F4 Heavy Chain × 1 Kappa Fab_1F4 Light Chain × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 ;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate ; × 2 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 GBRA1_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–429; UniProt 28–456

Gamma-aminobutyric acid receptor subunit gamma-2

物种未注明

UniProt P18507

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 7 其他聚合物 6 Gamma-aminobutyric acid receptor subunit beta-2 × 1 (P47870) Gamma-aminobutyric acid receptor subunit alpha-1 × 1 (P14867) Gamma-aminobutyric acid receptor subunit beta-1 × 1 (P18505) Gamma-aminobutyric acid receptor subunit alpha-2 × 1 (P47869) IgG2b Fab_1F4 Heavy Chain × 1 Kappa Fab_1F4 Light Chain × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 ;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate ; × 2 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 GBRG2_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–436; UniProt 40–475

Gamma-aminobutyric acid receptor subunit beta-1

物种未注明

UniProt P18505

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 7 其他聚合物 6 Gamma-aminobutyric acid receptor subunit beta-2 × 1 (P47870) Gamma-aminobutyric acid receptor subunit alpha-1 × 1 (P14867) Gamma-aminobutyric acid receptor subunit gamma-2 × 1 (P18507) Gamma-aminobutyric acid receptor subunit alpha-2 × 1 (P47869) IgG2b Fab_1F4 Heavy Chain × 1 Kappa Fab_1F4 Light Chain × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 ;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate ; × 2 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 GBRB1_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–449; UniProt 26–474

Gamma-aminobutyric acid receptor subunit alpha-2

物种未注明

UniProt P47869

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 7 其他聚合物 6 Gamma-aminobutyric acid receptor subunit beta-2 × 1 (P47870) Gamma-aminobutyric acid receptor subunit alpha-1 × 1 (P14867) Gamma-aminobutyric acid receptor subunit gamma-2 × 1 (P18507) Gamma-aminobutyric acid receptor subunit beta-1 × 1 (P18505) IgG2b Fab_1F4 Heavy Chain × 1 Kappa Fab_1F4 Light Chain × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 ;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate ; × 2 (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 GBRA2_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 E; PDB构建体 1–423; UniProt 29–451

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id9ctv
沉积日期 deposition_date2024-07-25
结构标题 titleNative human GABAA receptor of beta2-alpha1-gamma2-beta1-alpha2 assembly
关键词 keywordsIon channels, Heteropentamer, Receptor, Inhibitory., MEMBRANE PROTEIN; MEMBRANE PROTEIN
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

9ctv__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

9ctv__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

9ctv__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)40.68 Å
Rg(电子密度)40.27 Å
总 Rg40.64 Å
原子数14567
残基数1751
排除体积262050 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 9ctv__assembly_1__model_1 heptameric (7) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (13)

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7. 引用文献 (1)