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9ehi

Crystal structure of ENL YEATS in complex with histone H3 methacrylated at K18

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protein ENL

Homo sapiens

UniProt Q03111

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
10 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
11 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
12 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
13 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
14 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
15 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
16 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 2 Consistent with protein count
8 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） water × 1 Consistent with protein count
9 Protein heterocomplex Heteromer Protein 2 Histone H3.1 × 1 （P68431） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6hpw 6hpx 6hpy 6hpz 6hq0 6ht0 6ht1 6t1i 6t1j 6t1l 6t1m 6t1n

20 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5j9s 7e74 7e74 7e74 7e74 7e7c 7x88 7x8b 7x8b 7x8f 7x8f 7x8g

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ENL_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–145； UniProt 2–146 Author chain B； PDBConstruct 1–145； UniProt 2–146 Author chain C； PDBConstruct 1–145； UniProt 2–146 Author chain D； PDBConstruct 1–145； UniProt 2–146 Author chain E； PDBConstruct 1–145； UniProt 2–146 Author chain F； PDBConstruct 1–145； UniProt 2–146 Author chain G； PDBConstruct 1–145； UniProt 2–146 Author chain H； PDBConstruct 1–145； UniProt 2–146 Author chain I； PDBConstruct 1–145； UniProt 2–146 Author chain J； PDBConstruct 1–145； UniProt 2–146 Author chain K； PDBConstruct 1–145； UniProt 2–146 Author chain L； PDBConstruct 1–145； UniProt 2–146 Author chain M； PDBConstruct 1–145； UniProt 2–146 Author chain N； PDBConstruct 1–145； UniProt 2–146 Author chain O； PDBConstruct 1–145； UniProt 2–146 Author chain P； PDBConstruct 1–145； UniProt 2–146

Histone H3.1

OrganismNot specified

UniProt P68431

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
10 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
11 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
12 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
13 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
14 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
15 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
16 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 2 Consistent with protein count
8 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） water × 1 Consistent with protein count
9 Protein heterocomplex Heteromer Protein 2 Protein ENL × 1 （Q03111） 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2b2t 2b2u 2b2v 2b2w 2cv5 2l75 2ri7 2uxn 3a1b 3afa 3ayw 3aze

476 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name H31_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain Q； PDBConstruct 1–7； UniProt 16–22 Author chain R； PDBConstruct 1–7； UniProt 16–22 Author chain S； PDBConstruct 1–7； UniProt 16–22 Author chain T； PDBConstruct 1–7； UniProt 16–22 Author chain U； PDBConstruct 1–7； UniProt 16–22 Author chain V； PDBConstruct 1–7； UniProt 16–22 Author chain W； PDBConstruct 1–7； UniProt 16–22 Author chain X； PDBConstruct 1–7； UniProt 16–22 Author chain Y； PDBConstruct 1–7； UniProt 16–22 Author chain Z； PDBConstruct 1–7； UniProt 16–22 Author chain a； PDBConstruct 1–7； UniProt 16–22 Author chain b； PDBConstruct 1–7； UniProt 16–22 Author chain c； PDBConstruct 1–7； UniProt 16–22 Author chain d； PDBConstruct 1–7； UniProt 16–22 Author chain e； PDBConstruct 1–7； UniProt 16–22 Author chain f； PDBConstruct 1–7； UniProt 16–22

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9ehi
Deposition date deposition_date2024-11-22
Structure title titleCrystal structure of ENL YEATS in complex with histone H3 methacrylated at K18
Keywords keywordsENL, YEATS, PTM, methacrylation, acetylation, bromodomain, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9ehi__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9ehi__assembly_2__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9ehi__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.28 Å
Rg (electron density)17.30 Å
Total Rg18.37 Å
Atom count1226
Residues145
Excluded volume21865 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9ehi__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9ehi__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 9ehi__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 9ehi__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 9ehi__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 9ehi__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 9ehi__assembly_7__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 9ehi__assembly_8__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
9 1 9ehi__assembly_9__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
10 1 9ehi__assembly_10__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
11 1 9ehi__assembly_11__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
12 1 9ehi__assembly_12__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
13 1 9ehi__assembly_13__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
14 1 9ehi__assembly_14__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
15 1 9ehi__assembly_15__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
16 1 9ehi__assembly_16__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)