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3a1b

Crystal structure of the DNMT3A ADD domain in complex with histone H3

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA (cytosine-5)-methyltransferase 3A, Histone H3.1

Homo sapiens

UniProt P68431

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 ZINC ION × 3 1,2-ETHANEDIOL × 7 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2b2t 2b2u 2b2v 2b2w 2cv5 2l75 2ri7 2uxn 3a1b 3afa 3ayw 3aze

476 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name H31_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–20； UniProt 2–21

DNA (cytosine-5)-methyltransferase 3A, Histone H3.1

Homo sapiens

UniProt Q9Y6K1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 ZINC ION × 3 1,2-ETHANEDIOL × 7 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3a1a 3llr 3llr 3llr 3llr 3llr 8ba5

7 assemblies

Homodimer

None

Homotetramer
8tdr 8tdr 8te1 8te1 8te3 8te3 8te4 8te4

8 assemblies

Other homooligomers
9mpo

1 assemblies

Heteromeric or nucleic-acid complex
2qrv 2qrv 3a1b 3svm 3svm 4qbq 4qbr 4qbr 4qbs 4u7p 4u7t 5yx2

41 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DNM3A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 21–159； UniProt 476–614

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3a1b
Deposition date deposition_date2009-03-28
Structure title titleCrystal structure of the DNMT3A ADD domain in complex with histone H3
Keywords keywords;Zinc-finger, Histone binding, Chromosomal protein, DNA damage, DNA repair, DNA-binding, Methylation, Nucleosome core, Nucleus, Phosphoprotein, Alternative promoter usage, Metal-binding, Methyltransferase, S-adenosyl-L-methionine, Transferase ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3a1b__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3a1b__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3a1b__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）15.78 Å
Rg (electron density)14.55 Å
Total Rg15.51 Å
Atom count1204
Residues148
Excluded volume21351 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3a1b__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)