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9fbl

Structure of human protein kinase CK2 catalytic subunit (CK2alpha, CSNK2A1 gene product) in complex with the cyclic peptidomimetic compound 15 discovered by high-throughput screening

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Casein kinase II subunit alpha

Homo sapiens

UniProt P68400

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Cyclic peptidomimetic compound FMP35 × 1 NICOTINIC ACID × 1 SULFATE ION × 6 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Cyclic peptidomimetic compound FMP35 × 1 NICOTINIC ACID × 1 SULFATE ION × 3 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Cyclic peptidomimetic compound FMP35 × 1 NICOTINIC ACID × 1 SULFATE ION × 4 SODIUM ION × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
11uc 1na7 1pjk 2pvr 2zjw 3amy 3at2 3at3 3at4 3axw 3bqc 3c13

375 assemblies; showing the first 12

Homodimer
3h30 3u9c 5cu3 5kwh 5oqu 5orj 5ork 5ot5 5otd 5oth 5otl 5oto

21 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1jwh 3pe4 3pe4 3pe4 3pe4 3tax 3tax 3tax 3tax 3u87 3u87 4dgl

53 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CSK21_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 15–349； UniProt 1–335 Author chain B； PDBConstruct 15–349； UniProt 1–335 Author chain C； PDBConstruct 15–349； UniProt 1–335

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9fbl
Deposition date deposition_date2024-05-14
Structure title titleStructure of human protein kinase CK2 catalytic subunit (CK2alpha, CSNK2A1 gene product) in complex with the cyclic peptidomimetic compound 15 discovered by high-throughput screening
Keywords keywords;HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT ALPHA, CSNK2A1 GENE PRODUCT, INHIBITION OF CK2ALPHA/CK2BETA SUBUNIT INTERACTION, TRANSFERASE ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9fbl__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9fbl__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9fbl__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.06 Å
Rg (electron density)20.89 Å
Total Rg21.72 Å
Atom count2878
Residues333
Excluded volume50837 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9fbl__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9fbl__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 9fbl__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (3)