9l5r

Cryo-EM structure of the thermophile spliceosome (state ILS)

Method: ELECTRON MICROSCOPY D_max: 236.4 Å Quality: EXCELLENT

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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1. 结构基本信息 1. Structure Basics

条目编号 entry_id	9l5r
沉积日期 deposition_date	2024-12-23
结构标题 title	Cryo-EM structure of the thermophile spliceosome (state ILS)
关键词 keywords	Spilceosome, DHX15, DHX35, GPATCH1, SPLICING/RNA, SPLICING-RNA complex; SPLICING/RNA
实验方法 method	ELECTRON MICROSCOPY

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2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	90.11 Å
回转半径 Rg (电子) rg_electron	90.28 Å
零角强度 I(0) i0	35369100000.00
分子量 molecular_weight	1483000.0 kDa
排除体积 excluded_volume	1805300 Å³
包络体积 envelope_volume	3356300 Å³
水化壳体积 shell_volume	301210 Å³
包络直径 envelope_diameter	333.2 Å
壳层 Rg shell_rg	90.86 Å
包络 Rg envelope_rg	88.70 Å
形状 Rg shape_rg	90.37 Å
总 Rg total_rg	89.99 Å
总原子数 total_atoms	104144
残基数 n_residues	13299
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	236.4 Å
Rg (实空间) rg_real	87.10 Å
Rg 误差 (实空间) rg_real_error	0.53 Å
I(0) (实空间) i0_real	3.3830e+10
I(0) 误差 (实空间) i0_real_error	6.7360e+08
Rg (倒空间) rg_reciprocal	90.52 Å
I(0) (倒空间) i0_reciprocal	35410000000.0000
解质量估计 total_estimate	0.9141
解质量评级 solution_quality	EXCELLENT a EXCELLENT solution
P(r) 峰数 n_peaks	1
主峰位置 r_peak_primary	111.3 Å
偏度 Skewness skewness	0.171
峰度 Kurtosis kurtosis	-0.543
角度范围 angular_range	— – 0.0850 Å⁻¹
当前正则化参数 α current_alpha	0.9825
最高正则化参数 α highest_alpha	1926000000.0000
实空间数据点数 n_real_points	18
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 1.000; Stabil: 0.961; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.000

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合体信息 (44)

Entity 1 polymer

描述 description	U2 snRNA
分子量 formula_weight	61393.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	2
原子数 atom_count	104144

AGCUCUCUUUGCCUUUUGGCUUAGAUCAAGUGUAGUAUCUGUUCUUUUCAGUUUAAUCUCUGAAACUGCUCUACGGAGCAGAAUCGUGAUUAUACUAAUUUUUGGCCUUCGGCGGACUUCCCUCUGGGCUUGCCCAUGGUCGUCUGCCACAGUGUCCCUGGUAUUACACUGCCUCCAGGUGACGCGACCUUCC

Entity 2 polymer

描述 description	U5 snRNA
分子量 formula_weight	36997.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	5

UUGGAGUAGGCCAGCUCAGACCGAACUCAUUUCCUGCCUUUUACCGGAUGUGACCGUGAGUUGGCCUGAAAUACUCCCUAACCCAAUCUUUGGAAACUCUCUGGAUAUCCCAGAUU

Entity 3 polymer

描述 description	U6 snRNA
分子量 formula_weight	32443.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	6

GCCCUUCGGGGCAUUUGGUCAAUUUGAAACGAUACAGAGAAGAUUAGCAUGGCCCCUGCACUAAGGAUGACACGCUACUCAAAGAGACGCUACCAAUUUUU

Entity 4 polymer

描述 description	PRP8
分子量 formula_weight	285131.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	A

MLRPCALAIWQGFAPLQSRESSSRFSLFKPRPVPGFHQHTTLKGEVAISNCGEIVAPISFGLWRIFANRSRSNAGNTATCLRFRRLLPDGGPPPPPPPPPPPPGPPSDLPPPPPPSSSSLPPPPAIPAPPPPGYRPPSDPHIAKFAQKKKEWLRMQRNRFGEKRKGGFVETQKADMPPEHLRKIVKDIGDVSQKKYTSDKRSYLGALKFMPHAVLKLLENMPMPWEAAREVKVLYHVNGCLTLVNEIPRVIEPVFFAQWGSMWRTMRKEKSDRRLFKRMRFPPFDDEEPPLSWSENIEDVEPLEPIQMELDEDEDAAVYEWFYDHQPLIDTPHVNGPSYKRWNLTLPQMANLYRLSEPLVSDVVDPNYFYLFELKSFLTAKALNVALPGGPRFEPLYKDIDPNDEDFGEFNAMDRIIFRNPIRTETRVAYPYLYNSRPRSVHLSWHSYPQIVYTKTEDPELPAFYFDTSINPISSRAVAPKNLTVSHEDELFGKGNIEEPEEEAFVLPAAVEPFFADEELETEDTRSAIELWWAPYPFDRRSGRMVRAQDVPLIKHWYLEHCPPKQPVKVRVSYQKLLKTYVLNELHRKRPKSMQKQSLLRTLKQTKFFQQTTIDWVEAGLQVCRQGFNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLTKLIVDAQVQYRLGNIDAFQLADGIHYAFNHVGQLTGMYRYKYKLMHQIRSCKDLKHLIYYRFNTGPVGKGPGCGFWAPSWRVWLFFMRGIIPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMADLMDMMPEGIKQSKVNTVLQHLSEAWRCWKSNIPWKVPGLPAPIENIILRYVKAKADWWISVAHYNRERIRRGATVDKTVAKKNVGRLTRLWLKAEQERQHNHMKDGPYVSSEEAVAIYTTTVHWLEARKFSPIPFPSVSYKHDTKILILALERLREAYSTKGRLNQSQREELALIEQAYDSPGTTLERIKRFLLTQRAFKEVGIDMNDNYSTINPVYDVEPIEKISDAYLDQYLWYQADQRHLFPNWVKPSDSEVPPLLVYKWCQGINNLDKVWDTSNGECNVIIETQLSKVYEKIELTLLNSLLRLIMDHNLADYITAKNNVTLTYKDMSHVNSYGMIRGLQFSAFVFQYYGLILDLLILGPQRAAEIAGPPQSPNDFLQFQDRDTETRHPIRLYTRYIDKIWVFLRFTAEESRDLIQRFLTEQPDPNFENVIGFKSKKCWPRDSRMRLMRHDVNLGRAVFWDLKNRLPRSVTTIEWDDTFVSVYSKDNPNLLFSMCGFEVRILPKCRNQNDEFPVKDSVWSLVDNSTKERTAHAFLQVTEEDIQKFNNRIRQILMSSGSTTFTKIANKWNTALIALFTYYREAAVSTVNLLDTIVKCETKIQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMLSGSHILIPASDKRWCKQTDVGITHFRAGMSHDEETLIPNIARYIIPWEAEFIDSQRVWTEYSQKRLEAQQQNRRLTLEDLEDSWDRGLPRINTLFQKDRSTLSFDKGFRARAEFKIYQLMKSNPFWWTNPRHDGKLWNLNAYRTDVIQALGGVETILEHTLFKATGFPSWEGLFWEKSSGFEASMQFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEALSIESVQKETIHPRKSYKMNSSCADIQLFASHKWNVTRPSLLFDTKDVIEATTTNKFWIDVQLRYGDYDSHDIERYVRAKYLDYTTDSMSLYPSPTGLMIGIDLAYNLYSAYGQYFPGLKTLIQQAMAKIMKANPALYVLRERIRKGLQLYASESNQEFLNSQNYSELFSNQTQLFIDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQLIVTRKGLLDPLEVNLVDFPNISIRASELQLPFQAAMKVEKLGDMILRATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNQDKTKLILRPDKTVITQDHHIWPSLTDEDWIKVEMQLRDLILNDYGKKNNVNVASLTTSEVRDIILGMEISAPSLQRQQAAEIEKQQQEQAQLTAVTTKTQNVHGEEIIVTTTSQFEQQTFASKTEWRTRAIATSNLRTRANNMYVAPVDNDVDDITYVMPKNILKKFITIADLRVQVAGFLYGCSPADNDQVKEIRCIVMVPQIGGNRSVQLPQHLPQHEMLKGLEPLGLIHTMAGNELPYMSPADVTTHAKLVDAHPSWKNQNTLTVTVAFTPGSVSLSAWALTPLGYKWGVENKDPNVDNPQGFTTTMGERRQLLLSDKFKGFFLVPDTGKWNYSFMGSSFSGIEKKPYHVKLDTPLPFYSEQHRPIHFTSFNELEDIWVDRADNFA

Entity 5 polymer

描述 description	Pre-mRNA-splicing factor SYF2
分子量 formula_weight	36945.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	B

MPPAKKRKTEASQEPRPASEQQEQNGAQEEQPTVQDSTPEVESRSDDKKVSQSPTLATDPSDDTSEQPSESSTKNAALTAAQERLARFRALQARAKESSQQNLKEATKESQRLATDPSQLTALSRKHAIAAHKLLKAEIEDAGGDFERKRAWDWTVEEAERWDKRMKKKEAHRDDTAFRDYAREAEKTYKRQIRNMGAPDLEKYMREKLSAIEKAAAAGTLDIIETEDGEMIAVDKDGTFFSTANATDFAQHKPDKAAVDRLVADLRKAEEASLKRRREKLAKSGEEHGDVTYINEKNKQFNAKLARFYNKYTAEIRDSFERGTMV

Entity 6 polymer

描述 description	SNU114
分子量 formula_weight	113867.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	C

MWQRATRLRLSESFGPSTTDSNHTFPDLAATMDDDLYDEFGNFIGEEAESEEESDHGANAGVYAYDEYVDEAPEEPAEEQMDIDEEPPSNAVILHEDKQYYPTAAQVFGEGVETLVQEEDAQPLTQPIIAPVEQKKFSIQEADLPPVYFDRGFMTDLMNFPEQIRNIALAGHLHHGKTAFMDMLVLETHAIQERLDKRTGKKRDEQLRYTDVHVIERDRGLSIKAAPMSLVLSSTKGKSHLFNIIDTPGHVDFVDEVAAAFRLVDGVCLVVDVVEGVQVNTEQIIKHAVLEDIPLTLIINKMDRLILELKIPPTDAYFKLKHVIEEVNTVIENTIPGRGESKRLSPEKGNVLFACTSMGWCFTLQSFAKMYSESYGGVNVEEFARRLWGDVYFNPKKRTFTRKPIEEGAKRSFVNFVMEPIYKLYSHTISEGPEDLKRTLSKLGIFLKPSQYKADPKVLMKLVCEQFFGPSTAFVDMVIKHIPSPLEAAEKKLERYYTGPLDTKIAESMKNCDQNGPLVVHVTKLFNTIDAKSFYAFGRVMSGIARPGADVRVLGEGYTLDDEEDMVVSRISDVFIAETRYNIPTDGVPAGNFVLLGGVDNSIVKTATIVDKKFDNGEDAYVFKPLSHFTESVLKVAVEPINPSELPKMLDGIRKINKSYPLITTKVEESGEHIILGTGELYMDCVLHDLRKLYADMEVRVSDPVVRFCETVQDMSATKCYAITPNKKNTITMAAEPLDDGIAQDIESGAVKIKDPPRKVAKFFEEKYGWDKLAARSIWAFGPDEMGPNILQDDTLPTEVDKKRLATVKESIRQGFAWATREGPLCEEPIRNTKFRLIDVSLFPWWWPNYSDRSTCLLFLFLDGLPRLMEPMYSVSMTGPQSSVSMVYNILSRRRGHVLSDGPIAGTPLYRVNGLIPVIDSFGFETDLRINTPGQAMVSLVFDRWSIVPGDPLDREQVTRPLQMATAQATARDFVLKTRRRKGLSEDVTVAKFLEPEFYQSLLESGTLGEP

Entity 7 polymer

描述 description	SDE2
分子量 formula_weight	35780.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	D

MGRSSKINVLISTIEGTGLPPTLCLVLPPDSPVSSLRDELDSRLPTSASPYSTRLLLTTLSSRWVPLDSPLPISHFLPTCDPVADSDSEVDQLQNDFLHLRLAVPLLGGKGGFGSQLRAAGGRMSKRNKRANVNPEEEQGSSRNLDGRRLRTVTEAKALAEYLAIKPEMEKREKEARRKRWQEIIEMTERKQEEIRNGKRGAILDGKWVEEKEVMGERTREAVMEAMKAGAWKDNFISLGEPSSSRTVASSSSADEAMEEDEESENGSSKATTPPSEPDPAAEVKGKGKEKETPMKHPAPAAKKFFGFDDDDEFMSSDDEGGDES

Entity 8 polymer

描述 description	Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
分子量 formula_weight	38230.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	E

MSEKRPASDDPGEGQLVVKRQNVGSSRALTRTGDSAGALIQTTPRTSNLKAPLMELSGHTGEIFTAKFDPTGTLIASGSMDRTIMLWRVYGDCENYGVLNGHKAAILDLQWSRDGDILFSASADMHLASWDLTTGQRIRRYIGHEEIINAMDVTQRGEELLISGSDDGTIGIWDPRTKNAVDYIETDFPITAVAVSEAGNEIYSGGIDNDIKVWDIRKKAVVHTMLGHNDTITTLRVSPDGQQLLSYAMDSTARTWDIRPFAPTDRHIRTFDGAPLGLEKNLIRGSWSKDGKKIAVGAGDGTVVIWGSDTGKLLYKLPGHKGTVNCAEFAPDGAPIILSASSDRTMLLGELI

Entity 9 polymer

描述 description	CCDC12
分子量 formula_weight	25360.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	F

MSSYSSLSAAADERKARLAKLASLKRKQPEDDHPPSQDQQPEQSAAESKQEGDSSQASDPVLQHLSLRNYDPVTRGPKLGFEAPPTENLNTLTLEEKAAALEAEARRKAQEEQEAAAQARGLDITTLQPKKPNWDLKREFKQRMAVLDVRTENAIARMVRERLAEKKKAIVGASAAASGAADGAASGGGNNGKGEEGVLEGAEILEGMRMREKEEEEEARREKEAEEAEFGTA

Entity 10 polymer

描述 description	Putative pre-mRNA splicing protein
分子量 formula_weight	97944.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	I

MPSTLASDRQPDVALVCEDDAPYEQDILRNPGSIRPWLSYIEYKLQHGTLREQAFVMERACVQLPRSYKLWKMFRVNHISKLNPAIFATEYQKVNALFERALILLNKMPRIWEMYLKFLMQQPLVTFTRRTFDRALRALPITQHNRIWALYRPFANSAEGITAVKIWRRYMQVHPEDAEDFIELLIQCGLYTEAVKKYIEILNNPKFQSKNAKGHYELWSEMVDLLVEHAVDIETGHETGIDVERIIRSGIERFSDQRGKLWSGLATYWIRRGNFDRARDVFEEGITTVMTVRDFTMIFDAYVEFEESVIGTLMEAASRRAEKGVVDESADFDLDIRMMRFEHLMDRRPFLLNDVLLRQNPNNVAEWEKRVALWGDNKEEVVKTYTDAIAAINPKKAVGAFHLLWANYAKFYEKAGDLRTARIIMEKAVKVPFKSVNELADMWIEWAEMELRNKNFDEAVRIMAKATQAPKRSTVDYFDESLSPQQRVHKSWKLWSFYVDLVESTSSLEETRKIYERIFELRIATPQTVVNYANLLEEHHYYEESFKIYERGLDLFSYPVAFELWNLYLTKAVDRKISIERLRDLFEQAITDCPPKFAKVLYLMYGNLEEERGLARHAMRIYERATRAVADEDRADMFNFYITKSASNFGLASTRPIYERAIATLPDNEARDMCLKFADMEKRLGEIDRARAIYGHASQFCDPRTNPEFWAKWEQFEVQHGNEDTFKEMLRVKRSVQAKYNTDVNFIASQALARSQMLKQQQQQQQQQQQQQLQQQQQNGSSGAGDPEVADAMAQLERQARAPAGFVAASENIKGTIAPSTQSVEVSNPDAIDLDDMDE

Entity 11 polymer

描述 description	Suppressor of forked domain-containing protein
分子量 formula_weight	82195.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	J

MESSRGPPRVKNKAPAPIQISAEQLLREAVDRQETIIHKPTQRFADLEELKEYQGRKRREFEDYIRRNRLRLQNWFQYAQWELEQKEFARARSIFERALDVHPNNTQLWIRYIEAELKNRNINHARNLLDRAVTRLPRVSKLWYKYVYVMEMLGDIPGTRQVFDRWMKWEPDEDAWNAYIKLEKRYGEYERARQIFAAYTQVHPEPRTWLKWAKFEEEFGTADMVRDVFQSAIQYIAETLGDDAVDERLFIAFARFETRQKEYERARAIYKFGLDNLPRSRSMQLHAQYTTFEKQFGDKEGVEDVVLTKRRRLYEEQVKENPKNYDVWFDFARLEEMGGDPDRVREVYERAIAQVPPTQEKRHWRRYIFLFLFYAIWEEKDAKNIERARAIYDTCLNLIPHKKFTFAKVWIAKAHFEIRQGNLTAARKTLGRAIGMCPKDKLFREYIAIEQKLYEFDRCRTLYEKHALFNPANCQTWIRWAELERGLDDLDRTRAIFEVAISQPVLDMPEVVWKAYIDFEEEEGEYERARALYERLLQKADHPKVWISYAQFEINIPDTETEAQAAEGEEIPVSEAAKARARGVFERALKSMKERDLKAERVALLRAWLEFERTHGAAEDVERIRRQMPREVKKKRRIDEDTWEEYVDYVFPADEQQTKNLSNLLAMAKQWKEKTGGGIMGLGAGGS

Entity 12 polymer

描述 description	Putative pre-mRNA splicing protein
分子量 formula_weight	86636.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	L

MPVVKGGVWTNIEDEILKAAVSKYGLNQWARVSSLLARKTPKQCKARWNEWLDPSIKKIEWSREEDEKLLHLAKLMPTQWRTIAPIVGRTANQCLERYQKLLDEAEQREASELGLTGPDGGETRAPTAEDVRKLRPGEIDPDPETKPARPDTIDLDEDEKEMLSEARARLANTQGKKAKRKARERQQEESRRLAALQKRRELKTAGINIKITTRKKGQMDYNADIPFEKKPAPGFYDTTEEIARNEWQRAHFDPKKQQVGNKRKSDEEEEAERKKRKNNKDGPSASLQAALKAGQMQKLREAEQSSKRKPLILPAPQVSDSELDEIVKMGMIGERASAMARESENDATRGLVGNYSTLNTGAPIRTPRAPAQEDHIANEIRNIKALTETQSSLLGGENAPLAEGAGTTGFESVVPKKQVVSTPNPLATPLRQGPNGGATPLRPGQTPLRTPRDTFSLNATDGVSMEHALRQQLKQKLAALPKPKETEWELELPEEKQEPKTQEELEEDAADRDRRERELREARELAERRRRTQVMQRELPRTAVVDIDALLRAADEIEDPARALVAREAALLMAHDAAKYPLPGAPPGVKPVEIPRFSDDELAEARLQILMEMKEKPAPEVVHAIWNRREENLNALRLGLGYYDSDSEDGEDDVANIRATLEAALDRLMASAEKGNKLEKKLNLHLGGYKNRAEMLRKKLGEAHAALEKARNALAGFQVLRASEEQAIQRRLEALRAEVAFVSTRERKAQELYRKLRDELEELRLEQA

Entity 13 polymer

描述 description	Pre-mRNA-splicing factor SPF27
分子量 formula_weight	25550.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	K

MPAITTVHESLPYIDPEPTPEQRAAAEALIAEERAKVPDDPYHALLPPPLPPLNESRHLTPILQNELARLASSPDPQAAKMDALDFSRYEAPEMPSIDSSQSLEETASQLWETLKQAYTAQAYLSARRAHLALLDTHGKNAWLIGNWHLEGEVKAVEKELAETKREIDRVSLARQGMQEAAGAELKSLEETWKAGVGRVLETEAAAEKLRIEVLEERRRLAEAQAALAVGN

Entity 14 polymer

描述 description	Pre-mRNA-processing factor 19
分子量 formula_weight	51844.3 kDa
EC 编号 ec_number	2.3.2.27
来源方法 src_method	nat
拷贝数 entity_count	4

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	q,t,r,s

MLCALSGEIPEEPVVSKKTGVLFEKRLILKYLEEHNNIEPGTTEELDPETDLLPIKTSRVVRPRPPNFTSIPSLLKAFQDEWDALVLETYTTREQLARVREELATALYQHDAAVRVIARLTRERDEAREALARLTVTGAAPAAQNGEAMAVDSESLSEGLVEHVNEVQQQLMKTRKKRPIPQGWATADDVAALQQVAYTDLNVTQASSLDLENECAAVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIGTAKGWVKVYDAGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYADAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRLGMPVVGVKWGGEAKRLVVVSREGVVSVLGKKEE

Entity 15 polymer

描述 description	Putative bud site selection protein
分子量 formula_weight	17176.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	N

MPAIRPASKRKPPPDGFSDIEEDLLIFANKMKDAQNTPTDNIPKHQAQWPIFQIAHQRSRYVYELYYQKQAISKQLYDWLLKNGYADAMLIAKWKKQGYEKLCCLRCIQTKETNFNSTCICRVPRAQLKEDQDIQCVNCGCRGCASTD

Entity 16 polymer

描述 description	Peptidyl-prolyl cis-trans isomerase
分子量 formula_weight	18361.8 kDa
EC 编号 ec_number	5.2.1.8
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	S

MATDVALETTMGTIILELYNQHAPRTCENFKTLAARGYYDGTIFHRVIKDFMVQGGDPTGTGRGGRSIYGDTFEDEIHPGLRHTGAGILSMANAGPNTNGSQFFLTLAPTPWLDGKHTIFGRVKKGIRVLQRMGLVPTDADDRPKTEIKIIRAYVVGEGEEDDKQLV

Entity 17 polymer

描述 description	Pre-mRNA-splicing factor PRP46
分子量 formula_weight	54207.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	T

MATDVAVNGPDVSKLEALLRDNERTTRSLYASTTPDSGRKRIKLDPGLASEDPDITKSALSLRLHAEYGDVQTLPEAIAKKLSAAGPRKKKPKPGVAEDEAPSKSEEHTRKLIEGIPQAKPSAGAASSNALVLAHGKPSAAGAGAARPQRNEPQQLSLVRRSESLLAQPRPDWHPPWKLMRVISGHLGWVRALAVEPNNQWFASGAGDRTIKIWDLASGQLRLTLTGHISTVRGLAVSPRHPYMFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLKLHPTLDVLVTGGRDGVARVWDMRTRSNVHVLSGHTGTVADLVCQEADPQVITGSLDSTVRMWDLAAGKTMGVLTHHKKGVRALVTHPTEFTFATASTGSIKQWKCPEGAFMQNFEGHNAIINTLAVNDQNVLFSGGDNGSMSFWDWKSGYRFQSLDTTAQPGSLDAELGIMSSTFDMSGARLITGEADKTIKIWKEDTTATPETHPIEWKPSLVRRKY

Entity 18 polymer

描述 description	Cell cycle control protein
分子量 formula_weight	88163.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	U

MELDGLAAFEKALAAEKAERERAAREKEERRERKHRHHHHHHRSRSKSPKRDRDSDRHKHRSRSRDRDRHRDRDRDHDRHELPGRDGEKDRRSRHLSRERDSDEDRHRDRHSRRSRDEGDRDRSDRHRHRRRSRSRSKERDRDRYDKHTVKDTKDLKSSDPKADLPLPDEEKTPAGSTPLVRDAWMTAPSAMDIDYIHRRQKDKSPSPVREEPRLVLHKRELNTRLADDDWKEPAPAKKREVNYTFGDEGSEWRMTKLKGVYTIAEQTGRSVEDVALERYGSLEVFDEAMEEKMELDRRKLYGPGYVGKEKPTGNLYRERMAKTRPQPARSPSPEPQQGLVIEDKIQPAPPMDQSALNRLRAGYLRAKFRKAPEAAKLEEEYNKAAAAFTTGAASNNAIVLDASYNRMLAGPRHEVKAVTTKRGRERGQVEANEDMTIEDMISEERRTRGQPGGEGLRLAERIAKDARFENDLEYLEENAEWLAKRVHKTDLSLKNIAVNEYQKLNRILETCPLCYHEDRNPPQNLPIAPVISLGTRTYLTLAPEPEINGAEGGAVIVPLTHHTNLLECDDDEWEEIRNFMKSLTRLYHDQGRDVIFYENAAAPKRRQHAALVAVPIPYELGDTAPAFFREAMLSSDEEWAQHRKVIDTGKKAKEALGRMAFRRSIAKEMPYFHVWFNLDGGLGHIVEDENKWPKGDLFAREVIGGMLDAEPDVIKKQGRWTRSDERVEGFKKRWRKFDWTRVLTEGIVVQTDGASV

Entity 19 polymer

描述 description	Putative pre-mRNA splicing protein
分子量 formula_weight	42241.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	M

MPPQIKQDLNRAGWESTDFPSVCENCLPENPYVKMLKEDYGAECKLCTRPFTVFSWAGDGRAHGRKKRTNICLTCARLKNACQCCIMDLQFGLPIVIRDKALELIAPGPQSEINREYFAQNNERAIEEGRAGVEEYEKTDEKARELLRRLANSKPYFRKGRELDSEGNPVAGGSGSTVGGNAVVGAGLGGAGPIRTRDTRAAAAAGARTGGAGSARRGPGAALPPPGPKDWLPPADKSIMSLFITGIEDDLPEWKIRDFFKQYGKIKSLVVSHMTHCAFVNYETREGAEKAATELKGRAVIAGCPLRIRWSIPRPIGTMNKEERAEMLRDGRSAFPEANRKSAQKAIEAAGAQGGAAGGAAGGAAAEAQQDDLADLAIAAPPGAADVQYASLAGN

Entity 20 polymer

描述 description	Putative pre-mRNA splicing protein
分子量 formula_weight	45885.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	0

MAELETNPDVAVAVAEDSNEQKQENQLVAVNNEVAAPIEKKVKKIIRKKRRPARPQIDPALVKSERPPQTGTVFNIWYNKWSGGDREDKYLSQTHAKGRCNIARDSGYTRADSRPGSYFCLYFARGICPKGQDCDYLHRLPTIHDIFNPNVDCFGRDKFADYRDDMGGVGSFNRQNRTIYVGRIHVTDDIEEIVARHFAEWGQIERIRVLNNRGVAFITYTNEANAQFAKEAMAHQSLDHNEILNVRWATADPNPLAQKREQRRIEEQAAEAIRRALPAEFVAEIEGKDPEARKRRKLESSYGLEGYEAPDAVHFARGPNAVNPRGREGFELEREQQLMLEAPPETSQPAQIEAPPQAQEKKLAGGILSSRTLAALQGAKVAVATKDSKPEKPSGPLVAYGSDDEEDE

Entity 21 polymer

描述 description	Pre-mRNA-processing protein 45
分子量 formula_weight	65194.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	R

MASIAAGLAAALPKPKYSSEHEEPRATQRGPRIVSADQIDETQIVIRRTGPPPYPNRAGWRPRAPEDFGDGGAFPEIPVAQYPWGKNDSSSKSNALVVQVDSEGKVDYTAIARQGHSSDRIIHASFKDLIPLRQRAEAGQIDLSRPSKEEVEATAERTKNALAALVSGALAAQKPKNVQVNTKREATFVKYTPSAQMGNNTKKQERIIKIVERQRDPMEPPKFKHKKIPRGPPSPPPPVMHSPPRKLTAEDQEAWRIPPPVSMWKNPKGFTIPLDKRLAADGRQLQEVQINDKFAQFSEALFMADRHAREEVRQRAMMQQRLAEKERQQKEEHLRQLAQQARAERAAAAASGRRRSTRSRSGSYSGSESGSETDESERERRRARREKLKEEERKLRQSRMGAERRAQVLAREMDRDISEKIALGIAKPTMSGESMYDSRLFNQSSGFGATINEDNPYDKPLFAAQEAISSIYRPRTNAEYEDDEEAGEKEMERIRKGNRFGEALGRGTFKGTEDAQPREGPVQFEKDTETADPFNVDKFLSEVQKGSNSGGGKRGYGLQDEDSRQAKRSRVDDDENDD

Entity 22 polymer

描述 description	PRP17
分子量 formula_weight	61222.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	W

MPDFGEYPPNLPVRDALILRESQAQAPTANHAVVPYTGENLARPSYGPANPFRDTSSSSASASGSLKRKNNVLTGHAEEMYISEATFRAKHRAVEAVGGGVMRSNREMKEVNKRLREMREDKGSATIADGEGAYIGPWARYKRREEYEVVDKKGEEEDGDEYEEVEVTDEEEEVIESGTVLKAPEPAIARRKEAEEMGEERTEFLGESEYDYLGRTYMHVPQDLDVSLNKEVGSITNYIPKKLIYTWRHHGGKPITALQLFPRSSHLGLAGSADGVVKIFDVYRGRELLRSYSGHNKAITDLSFCNDGTKFLSGGFDRKIRLWDTETGQCVNRFNIGKTPHVIKFNPSSENGHEFLAGLSDKRIVQYDTRAGNDTVQEYDRHLGPINTIEYIDENRRFMSTSDDRSLKVWEYGIPVEIKTISEPDMFALTKSAQHPNGKYVLYQCSDNSIVAYSCSGDKFRQHRKKAWRGHNTAGSAIGLTCSPDGQFVASGDTSGSVCFWDFKTCKLYSKLTADSAGGIINCVAWSEQETSKVFTAGAKGEIKLWD

Entity 23 polymer

描述 description	Putative pre-mRNA splicing protein
分子量 formula_weight	28956.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	P

MTTAHRPTFDPARGKEALRGPAYHQRLLPAYTTLKFRQPGQGGAADKSTRDLRAELEAAEAAHYAKLKGAPIPGTSSSSENNTPAIAGSSASSVTGKRPLPSSSNGGGDRPPDDGDEDPEAKRRRILAETRDIDADDDSSSGSDKDSDSESGSADSDDSSDDEEAELQRELERVRRERMEKRAREEAERKAAEEARREEEIARGNPLLNKPDFTVKRRWDEDVVFKNQARGTEDKGKRKEFVNDLLRSDFHKRFMSKYVR

Entity 24 polymer

描述 description	Pre-mRNA-splicing factor
分子量 formula_weight	161045.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Y

MPPAKRIKSSADSRPNAGASGRPTLEDLEGENQFTNLARQHWLNVPQQAAKIKVKTDVLKRELYLWPGYGEDSSNYHVLLIILIVNAKRRERVSTWDIFADRPADFSDLFRRALSMTLDSSLSWTIRTHVLLFIIHAFQSLDYAIVRKECAPLVSISIWHNLSTEEKREALLDSNPHLRKAWRAATKRFESADDATKARLRFDRAWLYSLVLDFLTLLYSGNAKQEHVLYCERFVEFLTDLQSQLPTRRYVNTLLQDLHVLPALSLSPIYNDEGNGLLRELCNLFTHYTYFAVDDQSGVQLSREQAYDRHCAILAKLQRIAMKHFKEKLTVLALSNYGSIDKRSELEPLLQALTDDELVQLSNLMNIRTSYPDAARIPVDRKFIVEVLLTTFERRKTFQDAAQALSVLPTEETLFDISLKRTDQYDGSRPLALPKLNLQYLSVGDFLWRSFVLYRCESFYAIRQDLEDALIRLKPEVRRGGVTGFAGFSKMALPISKPVILDVMPPQVGDDKPSCVKAEVTIDLRRLTPQIRRDWESLRPDDVVFLLAVDASRQKQSANGGAVLSEAERLGLVHVRAAEIIQVLDDKGKAIRDPQAYFDGHTRSDIRKIQLRLDATSYKADTEANRNVYEDINLIVRRSSRENNFKPVLESIQDLTLSEVPLASWLHEVFLGYGDPAGATFKQLPNRLKKINFRDTFLDWQHLVESFPGKIIEPSDDVSSSFGPPYVLESVEKQVEEHPSKPSKKRRRDVEPALMSKVETLKVSTYKPPNNGPYPVDAPKLNKIRFTPTQIDAIYSGTQPGLTIIVGPPGTGKTDVAVQIISNIYHNFPEQKTLLVAHSNQALNQLFAKIVALDIDERHLLRLGHGEEELETEGSFSKHGRVESFLDNRQRFLYEVSRLAASMGAPGAHGNSAETAGYFNKVYVEPAWAKFNDIIQREDVGPEDIVRAFPFHAYFSDAPQPLFPPEADRETVLEIANGCYRHISKIFEELADVLPFEILRRDKDKANYLLTSEARIIAMTSTHAAMKRGEIASLGFQYDNVIMEEAAQITEIENFIPLALQKPKNGQMALQRVVLCGDHYQNSPVIQGLAFRHYANLEQSLFSRLVRLGVPTINLDQQGRARPSISNLYRWRYPQLGDLPHTQTEPEFLTANAGFRYDYQFVNVPDYRGMGESEPTPHFIQNLGEAEYAVAIFQYMRLLGYPASKISILATYAGQKALIKDVLAHRCAKNPIFGLPRVVTTVDKYQGEQNDYIILSLTRTTRVGYLRDLRRLTVALSRARLGLYILGRRAVFESCYELRDAFSLLLRRPDKLALVTGELWPSKRLLADETDDTKKLEGEVVMEGVEHLGQWVFEMTKTKIAELRKEKGLSEEVPVEMPKEVVSAEADEGYLPLDEEEGDGEEGEGERVKGFEIEDS

Entity 25 polymer

描述 description	Small nuclear ribonucleoprotein E
分子量 formula_weight	10967.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	a,j

MTSRGAPAGRRVLLPPINFLFRLLQQRTPVQIWLYEQLAIRITGVIRGFDEFMNLVIDDAVEIKLSPKTNEPESKRPLGQILLKGDNISLIQALSGSA

Entity 26 polymer

描述 description	Sm protein F
分子量 formula_weight	10727.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	b,l

MNTGFVPVNPRPFLQDLVNQDVIVRLKWGQTEYKGRLVSIDSYMNIQLANTEEFINYKSTGHLGQVLIRCNNVLWVTAAAGKQMTPTEDTKMEE

Entity 27 polymer

描述 description	Delta(14)-sterol reductase
分子量 formula_weight	66785.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	c,m

MAPKTKKQAVSRTQHYEFFGPPGAAAISFGLPLLVYAFAFACNDITGCPAPSLLHPKSLKLDVLKQEVGWPKNGIWGLASWRVTGWTLAYYLWLALLYRILPGDVVEGTQLRNGGRLKYKLNAFASSMFTLVICAAGTIAQGADFPLWTFIADNYVQILTANVIIAYTLATFVYIRSFSVKPGNPQLRELAVGGVTGNILYDWFIGRELNPRVTLPIIGEIDIKQWMELRPGLLGWTLMNCAFVAKQYRLYGYVTDSIVFVTAVQALYVLDSHYFEPAVLTTIDITTDGFGLMLSFGDIVWVPFIYTQSTRYLAVHPQKLGYLGLVGVTVLLVAGFAIFRLSNSQKNAFRTNPNDPSVKHLKYIETKAGTRLLISGWWGIARHINYLGDWLQAWPYCLPTGLAGYQILTAGSELAEGAVKMLDGRIVVPGEARGWGTIFTYFYVVYFATLLLHRDRRDDEKCSKKYGEDWEKYKEIVRWRIIPALLQKPRSECTEWEIAQIEEWEMANGPLSLLQTAVRSHTQVLISVRSGRKLLARVKAFDRHCNMILENVKEMWTETPVTNGKKGRPVNKDRFISKMFLRGDSVVIVLLS

Entity 28 polymer

描述 description	Small nuclear ribonucleoprotein Sm D1
分子量 formula_weight	13033.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	d,o

MKLVRFLMKCANETVTIELKNGAIVHGTIASVTPKMDTALRNVRYTPKGEEPYSVESLTVRGNTIRYYILPDSLPLDTLLIDDAPKPKNKARKEADRGRGRGRGRGGRGGRGGRARGR

Entity 29 polymer

描述 description	Sm protein B
分子量 formula_weight	21425.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	e,p

MSSSQNRQGKMAGYINWRMRVTLNDGRQMTGQMLAFDKHMNLVLADTEEFRKTKRMQAKPNSSTTQTLIQEEKRTLGLTIVRGANIIALSVESPPPADPSARLGKTTGAGIASTLTAGPGVARPAGRGAAAPISLAGPAPGVGGAVPPPPFPGFPAAAPPGFPGRGGPAPPGFPAAPFPPPAGFPGAPGFPPGFPPGGAPPPAGFNPPPRR

Entity 30 polymer

描述 description	Small nuclear ribonucleoprotein Sm D3
分子量 formula_weight	12708.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	f,u

MTSSIGIPIKLLNEAQGHIVTLELTTGQTYRGKLIEAEDNMNVQLKDITVTARDGRVSHLEQIYIRGSHVRFFIVPDMLRNAPMFRSRNVRGRGVGLARGRATVSRARASGRGR

Entity 31 polymer

描述 description	Small nuclear ribonucleoprotein G
分子量 formula_weight	9259.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	g,k

MAPAQPELKKYLDKRLFVELNGSRRVIGVLRGYDVFLNIVLDDAVEERPNGEKVKLGMVTIRGNSVVILEPLERIGDDRPGR

Entity 32 polymer

描述 description	;U2 small nuclear ribonucleoprotein A' ;
分子量 formula_weight	27249.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	h

MRLTAELIQNSLSYLNPLKERELDLRGHRIPAIENLGVAGPHDAIDLTDNDIQVLGNFPLSPRLRTLLVARNRVAMIHPTLPNAIPNLRNLVLASNNLTELSDLDVLGKFPRLTHLVLMDNPVTKKEVKDAERNKAKELFGTAEAPTELAAKIMGIKSKTFDVTAVPNGETQKSKLSRLKLTEKERKKLQEMIKKATSLEEIIRLEKYLNEGRLPPGIMVVEDAMEEHISMTSQSVDIWDRD

Entity 33 polymer

描述 description	;U2 small nuclear ribonucleoprotein B'-like protein ;
分子量 formula_weight	21744.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	i

MSTRGAPPPNLPAKVAAIPPNQTLYVTNLPSAKIQKEDLRTALYMLFSTYGSVLDVVALKTMKMRGQAHIVYKDIQTATMAMRALDGFEFLGRPMKISYAKGKSHIIAKLDGTFKPPTAAKEVEVTDLQHSIFNAPVPGQPGSVTAPAKSSSLPPKPPGGGDQPMPDVGATETRGVKRPREEELEEESDQDVAMEEESDED

Entity 34 polymer

描述 description	Nineteen complex-related protein 2-domain-containing protein
分子量 formula_weight	56472.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	CY

MAAFGAKRKPRIIKAFDDDDEDLSLPLSSGGEDKQAGEELPPPARIKFGRTKFTKSSALRKNAMIGNDDTDSPNATSARDDDDDDENSGAPVVVRPSSVNKGSLSKIKKRPAASRLSFGPSAGAEDDDEEAEVVIQPRKMLNQRAVENSALRANSSLPTRFGGEENRPKYSKEYLAELQSATFNTPQNLADLKIHDDDEMQLDEMELEGALIVPSNEVAVPGASTTQTTHIPTEAEIRERKERRARLAHEAKFIPLDDEFNSDNEGAQPSHPILNLPSKQKRRDTRLIREDEDLYEGFDEFVSDGNLALGRKAEKAVLQRHRQEMAELIEAAQAEDNDEAASDDSEAEERAAYEEAQVRAAMDGLRGKYREEHLERGGGADLYEGRGPDDIPRMKPLPKLGDVLQRIREAIQGLEGEVVRKRSRIEGLEKEKAEILVREKEVQEILNQAGQKYQEVVGGLGVHNVPKIVAGQSPLRPFPPGLAREMPTERGLESYGATPIRRYGGEEDDG

Entity 35 polymer

描述 description	G-patch domain-containing protein
分子量 formula_weight	110801.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Cb

MARLDDLQFDPARLKNSSVDAYSSSDSDGDSDSDDYVIPSRNPHDDEFADYNPRKRRRTGRDPKESAALGIFAEDSDEDEGPARRWKHKPLRNRGVNFVSGGQQKKEEDSSESDEEESNDDERKQQEAVDNEYDDDDPGGVPAALTEDDVDEDEDDEMGGVGLGFKPSSTSATSQPQGGLGWTLPTQQETTTKKPPPFQRFVKSKIDPSNPLGPGFTPTSARAPTLLARNDEPTPPRTALPSAFQPTKDGKTKINPNSFGARMLAKMGYKEGQGLGKDGQGRNVIIEVNLRPQGVGLGAVKEKTKQEREEEKRQARLRGEEVIDSSEEERKKKAAKKKKGLAGKIGSGSGSGASTPRPQKPKYLTMEEIKKVAPGLHIPEAFTPILDMTGPEKKLLTSTSGLMTPTGGTGAAPTAESVEAAEKRKLIKRAQADFMAILEEWQSLQERKAYIDLQLQQERQELEELEASLQGNRSVTTACETALRPPESGELDQKKDLEYRLERIIAGLASATTSLIVGTMLPQVRDELGALAVAAIHPLFNQFRQLWDPLEEPKPSFVDGMKEIRSLLGLDQKPKKKTYRKPSATPYETMMYELWLRTVAASVREWDVREPEPLIAVLEAWDALLPGFVRAQLLRDVVRKLEEAVEKWQPRKHTHNLPHRWIFPWLPYLPASHLDAKAATGLVADVRRKFRTLIDAWDFSRGVIPGLKHWKQVLWPEHGRSSDYWTPLMMNHLLPAMAKYLRQKFRVDPRDQGPYIDILDKVFEWTEVIRPEMVGEVIVAEVFPMWHDALYQWLLLEDANYEEIGQWFEWWQDQVFPDDIKALPSITAEFEKGTAMIERALDLGNRAKDELKPPERGPALRTGREERRRTEKEREREREREKEKERATVGKPPEEITFRQVLEEWCQEHDLQFMPERNKIHAEGPLYRISGPDGKKGVSVYFKGNSVFVLMKDRKPLEFRRDDEAEWGILLDMVY

Entity 36 polymer

描述 description	RNA helicase
分子量 formula_weight	87155.5 kDa
EC 编号 ec_number	3.6.4.13
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Cc

MADITKGTKRLSGEAEGSQDSKRVKTNGDKMDAKNPYLAHLEEKPEADFESLLDKLERRNTTAKQAEAVEDSDINPWTGQRHSERYFKILKARRKLPVNKQRQEFLDLYHNNQILVFVGETGSGKTTQIPQYVLYDELPHQTGKLIACTQPRRVAAMSVAQRVADELDVKLGEEVGYSIRFENKTSSKTLLKYMTDGQLLREAMHDRDMSRYSCIILDEAHERTLATDILMALLKQLSERRKDLKIIVMSATLDAQKFQSYFFNAPLLAVPGRTHPVEIFYTPEAERDYVEAAIRTVLQIHACEPEGDILLFLTGEEEIEDACRRISLEVDEMIRESDAGPMSVYPLYGTLPPHQQQRIFEKAPQPFRPGGRPGRKCIVATNIAETSLTIDGIVYVVDPGFSKQKIYNPRTRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFKKELIEQTYPEILRSNLSNTVLELKKLGVEDLVHFDLMDPPAPETMMRALEELNYLACLDDDGELTPLGNLASEFPLDPALAVMLISSPEFYCSNEILSITSLLSVPQIWVRPANARKRADEMKAQFAHPDGDHLTLLNAYHAYKGAEARGEDMKKWCHEHFLSYRHLSSADNVRAQLKKIMETHGIELVSTPFHDKNYYTNIRRALLAGFFMQVAMRESSNSKVYKTVKDEQLVLIHPSTTVTTPYEWVVYNEFVLTTKQYVRTVTNIRPEWLLEIAPVYYDLSTFQKGEIKNALTRVAEKIRRQQAMKASKA

Entity 37 polymer

描述 description	Unknown mRNA
分子量 formula_weight	22185.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	7

GUAXAXAXNXXXXXNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNXXAXAXXXAXXXX

Entity 38 polymer

描述 description	Putative cyclophilin protein
分子量 formula_weight	16600.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Ci

MSDAARWKATVYVGGLAPAVTATVLHEAFLPFGEIAEINLPRNENPNTASTEPHRGFAYVEFEDPEDAKEAIDNMDQSELFGRVIKVSAAKPPKSAGQGLGSKTAVWEQEGWLAEHAVSEEDRLAAERAKNARPNEDPMQGLEDLDVAGPKPE

Entity 39 polymer

描述 description	Unknown protein
分子量 formula_weight	1890.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	H

XXXXXXXXXXXXXXXXXXXXXX

Entity 40 non-polymer

描述 description	;N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate) ;
分子量 formula_weight	487.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 41 non-polymer

描述 description	MAGNESIUM ION
分子量 formula_weight	24.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 42 non-polymer

描述 description	GUANOSINE-5'-TRIPHOSPHATE
分子量 formula_weight	523.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 43 non-polymer

描述 description	INOSITOL HEXAKISPHOSPHATE
分子量 formula_weight	660.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 44 non-polymer

描述 description	ZINC ION
分子量 formula_weight	65.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	6

▶

7. 引用文献 (1)

▶

晶胞边长 a length_a	1.000 Å
晶胞边长 b length_b	1.000 Å
晶胞边长 c length_c	1.000 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	—

空间群 space_group	P 1
空间群编号 int_tables_number	1
晶系 crystal_system	triclinic

分辨率 resolution	2.80 Å
分辨率测定方法 resolution_method	—
颗粒数 num_particles	77668

fit	/app/data/saxs_computation/l5/9l5r/9l5r.fit
pddf	/app/data/pr_computation/l5/9l5r/9l5r.pr.out
profile	/app/data/saxs_computation/l5/9l5r/9l5r.dat

Cryo-EM structure of the thermophile spliceosome (state ILS)

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

1. 结构基本信息 1. Structure Basics

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

冷冻电镜 EM 3D

5. 实体与聚合体信息 (44)

Entity 1 polymer

聚合体 Polymer

Entity 2 polymer

聚合体 Polymer

Entity 3 polymer

聚合体 Polymer

Entity 4 polymer

聚合体 Polymer

Entity 5 polymer

聚合体 Polymer

Entity 6 polymer

聚合体 Polymer

Entity 7 polymer

聚合体 Polymer

Entity 8 polymer

聚合体 Polymer

Entity 9 polymer

聚合体 Polymer

Entity 10 polymer

聚合体 Polymer

Entity 11 polymer

聚合体 Polymer

Entity 12 polymer

聚合体 Polymer

Entity 13 polymer

聚合体 Polymer

Entity 14 polymer

聚合体 Polymer

Entity 15 polymer

聚合体 Polymer

Entity 16 polymer

聚合体 Polymer

Entity 17 polymer

聚合体 Polymer

Entity 18 polymer

聚合体 Polymer

Entity 19 polymer

聚合体 Polymer

Entity 20 polymer

聚合体 Polymer

Entity 21 polymer

聚合体 Polymer

Entity 22 polymer

聚合体 Polymer

Entity 23 polymer

聚合体 Polymer

Entity 24 polymer

聚合体 Polymer

Entity 25 polymer

聚合体 Polymer

Entity 26 polymer

聚合体 Polymer

Entity 27 polymer

聚合体 Polymer

Entity 28 polymer

聚合体 Polymer

Entity 29 polymer

聚合体 Polymer

Entity 30 polymer

聚合体 Polymer

Entity 31 polymer

聚合体 Polymer

Entity 32 polymer

聚合体 Polymer

Entity 33 polymer

聚合体 Polymer

Entity 34 polymer

聚合体 Polymer

Entity 35 polymer