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9lev

Cryo-EM structure of human ZAC in nanodisc in apo state

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Ligand-gated cation channel ZACN,Genome polyprotein

Enterovirus A71

UniProt B6F2F5

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 5 其他Polymer 10 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 5 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8soj 8sok 9let 9leu 9lev 9lex 9ley 9lez 9lrc 9lre 9r6h 9r6h

12 assemblies

View Construct and Data Evidence
UniProt name B6F2F5_HE71
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 468–705； UniProt 4–241 Author chain B； PDBConstruct 468–705； UniProt 4–241 Author chain C； PDBConstruct 468–705； UniProt 4–241 Author chain D； PDBConstruct 468–705； UniProt 4–241 Author chain E； PDBConstruct 468–705； UniProt 4–241

Ligand-gated cation channel ZACN,Genome polyprotein

Enterovirus A71

UniProt Q401N2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 5 其他Polymer 10 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 5 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8yx6 8yx7 8yx8 9let 9leu 9lev 9lex 9ley 9lez

9 assemblies

View Construct and Data Evidence
UniProt name ZACN_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–412； UniProt 1–412 Author chain B； PDBConstruct 1–412； UniProt 1–412 Author chain C； PDBConstruct 1–412； UniProt 1–412 Author chain D； PDBConstruct 1–412； UniProt 1–412 Author chain E； PDBConstruct 1–412； UniProt 1–412

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9lev
Deposition date deposition_date2025-01-07
Structure title titleCryo-EM structure of human ZAC in nanodisc in apo state
Keywords keywordsCys-loop receptor, homopentamer, cation channel, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9lev__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9lev__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9lev__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.68 Å
Rg (electron density)36.87 Å
Total Rg37.35 Å
Atom count12685
Residues1555
Excluded volume230060 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9lev__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)