9mxc

Cryo-EM Structure of Human Enterovirus D68 USA/IL/14-18952 in Complex with Fc-MFSD6(L3)

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

viral protein 1

物种未注明

UniProt A0A1I9KHM1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 300 其他聚合物 60 viral protein 2 × 60 (A0A1B0T636) viral protein 3 × 60 (A0A097BW17) viral protein 4 × 60 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 60 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 60 SODIUM ION × 180 water × 300 与蛋白数一致
2 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 2 × 1 (A0A1B0T636) viral protein 3 × 1 (A0A097BW17) viral protein 4 × 1 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致
3 其他组合 异源复合物 蛋白 25 其他聚合物 5 viral protein 2 × 5 (A0A1B0T636) viral protein 3 × 5 (A0A097BW17) viral protein 4 × 5 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 5 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 5 SODIUM ION × 15 water × 25 与蛋白数一致
4 其他组合 异源复合物 蛋白 30 其他聚合物 6 viral protein 2 × 6 (A0A1B0T636) viral protein 3 × 6 (A0A097BW17) viral protein 4 × 6 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 6 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 6 SODIUM ION × 18 water × 30 与蛋白数一致
5 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 2 × 1 (A0A1B0T636) viral protein 3 × 1 (A0A097BW17) viral protein 4 × 1 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A1I9KHM1_HED68
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–297; UniProt 565–861

viral protein 2

物种未注明

UniProt A0A1B0T636

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 300 其他聚合物 60 viral protein 1 × 60 (A0A1I9KHM1) viral protein 3 × 60 (A0A097BW17) viral protein 4 × 60 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 60 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 60 SODIUM ION × 180 water × 300 与蛋白数一致
2 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 3 × 1 (A0A097BW17) viral protein 4 × 1 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致
3 其他组合 异源复合物 蛋白 25 其他聚合物 5 viral protein 1 × 5 (A0A1I9KHM1) viral protein 3 × 5 (A0A097BW17) viral protein 4 × 5 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 5 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 5 SODIUM ION × 15 water × 25 与蛋白数一致
4 其他组合 异源复合物 蛋白 30 其他聚合物 6 viral protein 1 × 6 (A0A1I9KHM1) viral protein 3 × 6 (A0A097BW17) viral protein 4 × 6 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 6 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 6 SODIUM ION × 18 water × 30 与蛋白数一致
5 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 3 × 1 (A0A097BW17) viral protein 4 × 1 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A1B0T636_HED68
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–237; UniProt 81–317

viral protein 3

物种未注明

UniProt A0A097BW17

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 300 其他聚合物 60 viral protein 1 × 60 (A0A1I9KHM1) viral protein 2 × 60 (A0A1B0T636) viral protein 4 × 60 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 60 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 60 SODIUM ION × 180 water × 300 与蛋白数一致
2 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 2 × 1 (A0A1B0T636) viral protein 4 × 1 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致
3 其他组合 异源复合物 蛋白 25 其他聚合物 5 viral protein 1 × 5 (A0A1I9KHM1) viral protein 2 × 5 (A0A1B0T636) viral protein 4 × 5 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 5 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 5 SODIUM ION × 15 water × 25 与蛋白数一致
4 其他组合 异源复合物 蛋白 30 其他聚合物 6 viral protein 1 × 6 (A0A1I9KHM1) viral protein 2 × 6 (A0A1B0T636) viral protein 4 × 6 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 6 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 6 SODIUM ION × 18 water × 30 与蛋白数一致
5 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 2 × 1 (A0A1B0T636) viral protein 4 × 1 (Q68T42) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A097BW17_HED68
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–247; UniProt 318–564

viral protein 4

物种未注明

UniProt Q68T42

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 300 其他聚合物 60 viral protein 1 × 60 (A0A1I9KHM1) viral protein 2 × 60 (A0A1B0T636) viral protein 3 × 60 (A0A097BW17) Major facilitator superfamily domain-containing protein 6 × 60 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 60 SODIUM ION × 180 water × 300 与蛋白数一致
2 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 2 × 1 (A0A1B0T636) viral protein 3 × 1 (A0A097BW17) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致
3 其他组合 异源复合物 蛋白 25 其他聚合物 5 viral protein 1 × 5 (A0A1I9KHM1) viral protein 2 × 5 (A0A1B0T636) viral protein 3 × 5 (A0A097BW17) Major facilitator superfamily domain-containing protein 6 × 5 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 5 SODIUM ION × 15 water × 25 与蛋白数一致
4 其他组合 异源复合物 蛋白 30 其他聚合物 6 viral protein 1 × 6 (A0A1I9KHM1) viral protein 2 × 6 (A0A1B0T636) viral protein 3 × 6 (A0A097BW17) Major facilitator superfamily domain-containing protein 6 × 6 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 6 SODIUM ION × 18 water × 30 与蛋白数一致
5 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 2 × 1 (A0A1B0T636) viral protein 3 × 1 (A0A097BW17) Major facilitator superfamily domain-containing protein 6 × 1 (Q6ZSS7) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 POLG_HED68
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–30; UniProt 29–58

Major facilitator superfamily domain-containing protein 6

Homo sapiens

UniProt Q6ZSS7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 300 其他聚合物 60 viral protein 1 × 60 (A0A1I9KHM1) viral protein 2 × 60 (A0A1B0T636) viral protein 3 × 60 (A0A097BW17) viral protein 4 × 60 (Q68T42) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 60 SODIUM ION × 180 water × 300 与蛋白数一致
2 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 2 × 1 (A0A1B0T636) viral protein 3 × 1 (A0A097BW17) viral protein 4 × 1 (Q68T42) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致
3 其他组合 异源复合物 蛋白 25 其他聚合物 5 viral protein 1 × 5 (A0A1I9KHM1) viral protein 2 × 5 (A0A1B0T636) viral protein 3 × 5 (A0A097BW17) viral protein 4 × 5 (Q68T42) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 5 SODIUM ION × 15 water × 25 与蛋白数一致
4 其他组合 异源复合物 蛋白 30 其他聚合物 6 viral protein 1 × 6 (A0A1I9KHM1) viral protein 2 × 6 (A0A1B0T636) viral protein 3 × 6 (A0A097BW17) viral protein 4 × 6 (Q68T42) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 6 SODIUM ION × 18 water × 30 与蛋白数一致
5 其他组合 异源复合物 蛋白 5 其他聚合物 1 viral protein 1 × 1 (A0A1I9KHM1) viral protein 2 × 1 (A0A1B0T636) viral protein 3 × 1 (A0A097BW17) viral protein 4 × 1 (Q68T42) ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SODIUM ION × 3 water × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MFSD6_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 E; PDB构建体 1–9; UniProt 200–208

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id9mxc
沉积日期 deposition_date2025-01-18
结构标题 titleCryo-EM Structure of Human Enterovirus D68 USA/IL/14-18952 in Complex with Fc-MFSD6(L3)
关键词 keywordsVirus, Glycan, MFSD6, Receptor; VIRUS
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

9mxc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

9mxc__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

9mxc__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)0.00 Å
Rg(电子密度)136.90 Å
总 Rg137.00 Å
原子数768240
残基数49200
排除体积6903000 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 9mxc__assembly_1__model_1 300-meric (300) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 9mxc__assembly_2__model_1 pentameric (5) 排除 — —
排除原因: 辅助对称表示,不是完整或代表性的 biological assembly。
3 1 9mxc__assembly_3__model_1 25-meric (25) 排除 — —
排除原因: 辅助对称表示,不是完整或代表性的 biological assembly。
4 1 9mxc__assembly_4__model_1 30-meric (30) 排除 — —
排除原因: 辅助对称表示,不是完整或代表性的 biological assembly。
5 1 9mxc__assembly_5__model_1 pentameric (5) 排除 — —
排除原因: 辅助对称表示,不是完整或代表性的 biological assembly。
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (8)

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7. 引用文献 (1)