The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links.
Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
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2. Structure Basics 2. Structure Basics
Entry ID entry_id
9n5q
Deposition date deposition_date
2025-02-04
Last revision last_revision
2025-11-26
Structure title title
X-ray structure of SARS-CoV-2 main protease M49I covalently bound to inhibitor GRL-051-22 at 1.50 A
Keywords keywords
;Main protease, 3-chymotrypsin-like protease, Mpro, 3CLpro, Mutant, Structural Genomics, Center for Structural Biology of Infectious Diseases, CSBID, VIRAL PROTEIN
;; VIRAL PROTEIN
Experimental Method method
X-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
9n5q__assembly_1__model_1
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
X-ray structure of SARS-CoV-2 main protease M49I covalently bound to inhibitor GRL-051-22 at 1.50 A
To Be Published
PRIMARY
;Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors.
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