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CryoEM structure of human astrovirus 1 spike in complex with human neonatal Fc receptor

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

IgG receptor FcRn large subunit p51

Homo sapiens

UniProt P55899

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 10 Beta-2-microglobulin × 2 （P61769） Capsid polyprotein VP90 × 2 （A0A3G6VE21） Capsid polyprotein VP70 × 4 （O12792） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3m17 3m17 3m17 3m17 3m1b 3m1b 3m1b 3m1b

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1exu 4k71 4k71 4k71 4n0f 4n0f 4n0f 4n0f 4n0u 5bjt 5bjt 5bjt

63 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FCGRN_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain G； PDBConstruct 1–267； UniProt 24–290 Author chain I； PDBConstruct 1–267； UniProt 24–290

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 10 IgG receptor FcRn large subunit p51 × 2 （P55899） Capsid polyprotein VP90 × 2 （A0A3G6VE21） Capsid polyprotein VP70 × 4 （O12792） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain H； PDBConstruct 1–99； UniProt 21–119 Author chain J； PDBConstruct 1–99； UniProt 21–119

Capsid polyprotein VP90

OrganismNot specified

UniProt A0A3G6VE21

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 10 IgG receptor FcRn large subunit p51 × 2 （P55899） Beta-2-microglobulin × 2 （P61769） Capsid polyprotein VP70 × 4 （O12792） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
9nav

1 assemblies

View Construct and Data Evidence
UniProt name A0A3G6VE21_HASV1
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–644； UniProt 1–644 Author chain D； PDBConstruct 1–644； UniProt 1–644

Capsid polyprotein VP70

OrganismNot specified

UniProt O12792

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 10 IgG receptor FcRn large subunit p51 × 2 （P55899） Beta-2-microglobulin × 2 （P61769） Capsid polyprotein VP90 × 2 （A0A3G6VE21） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
9wye

1 assemblies

Homotetramer

None

Other homooligomers
9nau 9nau 9nau 9nau 9nau

5 assemblies

Heteromeric or nucleic-acid complex
9nav

1 assemblies

View Construct and Data Evidence
UniProt name CAPSD_HASV1
Isoform —
PDB entities 4
Chains and sequence ranges Author chain B； PDBConstruct 1–418； UniProt 1–418 Author chain C； PDBConstruct 1–418； UniProt 1–418 Author chain E； PDBConstruct 1–418； UniProt 1–418 Author chain F； PDBConstruct 1–418； UniProt 1–418

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9nav
Deposition date deposition_date2025-02-12
Structure title titleCryoEM structure of human astrovirus 1 spike in complex with human neonatal Fc receptor
Keywords keywords;spike protein, FcRn, FCGRT, VP90, ORF2, VIRUS, Structural Genomics, Center for Structural Biology of Infectious Diseases, CSBID, VIRAL PROTEIN ;; VIRAL PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9nav__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9nav__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9nav__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）53.40 Å
Rg (electron density)53.02 Å
Total Rg53.15 Å
Atom count24270
Residues3168
Excluded volume431260 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9nav__assembly_1__model_1 decameric （10） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)