9ntq

;Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 T-cell engager, for the treatment of GPC3+ solid tumors ;

Method: ELECTRON MICROSCOPY D_max: 117.1 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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1. 结构基本信息 1. Structure Basics

条目编号 entry_id	9ntq
沉积日期 deposition_date	2025-03-18
结构标题 title	;Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 T-cell engager, for the treatment of GPC3+ solid tumors ;
关键词 keywords	GRIPS, ONCOPROTEIN-IMMUNE SYSTEM complex; ONCOPROTEIN/IMMUNE SYSTEM
实验方法 method	ELECTRON MICROSCOPY

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2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	34.61 Å
回转半径 Rg (电子) rg_electron	34.32 Å
零角强度 I(0) i0	44127200.00
分子量 molecular_weight	52110.0 kDa
排除体积 excluded_volume	65180 Å³
包络体积 envelope_volume	88106 Å³
水化壳体积 shell_volume	24755 Å³
包络直径 envelope_diameter	116.5 Å
壳层 Rg shell_rg	35.34 Å
包络 Rg envelope_rg	33.98 Å
形状 Rg shape_rg	34.24 Å
总 Rg total_rg	34.70 Å
总原子数 total_atoms	4513
残基数 n_residues	470
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	117.1 Å
Rg (实空间) rg_real	35.02 Å
Rg 误差 (实空间) rg_real_error	1.39 Å
I(0) (实空间) i0_real	4.4130e+07
I(0) 误差 (实空间) i0_real_error	8.3540e+05
Rg (倒空间) rg_reciprocal	34.77 Å
I(0) (倒空间) i0_reciprocal	44120000.0000
解质量估计 total_estimate	0.7756
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	1
主峰位置 r_peak_primary	25.5 Å
偏度 Skewness skewness	0.488
峰度 Kurtosis kurtosis	-0.672
角度范围 angular_range	— – 0.2300 Å⁻¹
当前正则化参数 α current_alpha	0.0000
最高正则化参数 α highest_alpha	3525000.0000
实空间数据点数 n_real_points	47
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.642; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.459; Smooth: 0.694

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合体信息 (3)

Entity 1 polymer

描述 description	Glypican-3
分子量 formula_weight	50962.0 kDa
来源方法 src_method	man
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	A
原子数 atom_count	4513

CHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMS

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI 分类编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

Entity 2 polymer

描述 description	A0226015A08
分子量 formula_weight	12610.1 kDa
来源方法 src_method	man
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	B

DVQLVESGGGLVQPGGSLRLSCVASGSXFRSVFSSSTMEWYRQPPGKKRELVARIAPGDGTNYGALYADSVKGRFTISRDDAKKTVDLQMNSLKPEDTGVYFCASGVAWGQGTLVTVSS

来源 Source

来源生物 organism	Lama glama
通用名 common_name	llama
NCBI 分类编号 ncbi_taxonomy_id	9844
宿主生物 host_organism	Escherichia coli

Entity 3 non-polymer

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	221.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

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7. 引用文献 (1)

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分辨率 resolution	4.04 Å
分辨率测定方法 resolution_method	—
颗粒数 num_particles	88803

fit	/app/data/saxs_computation/nt/9ntq/9ntq.fit
pddf	/app/data/pr_computation/nt/9ntq/9ntq.pr.out
profile	/app/data/saxs_computation/nt/9ntq/9ntq.dat

;Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 T-cell engager, for the treatment of GPC3+ solid tumors ;

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

1. 结构基本信息 1. Structure Basics

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

4. 晶体学与实验 4. Crystallography & Experiment

冷冻电镜 EM 3D

5. 实体与聚合体信息 (3)

Entity 1 polymer

聚合体 Polymer

来源 Source

Entity 2 polymer

聚合体 Polymer

来源 Source

Entity 3 non-polymer

7. 引用文献 (1)

8. 文件与曲线 (10)

Files (7)

Curves (3)