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9pr5

Cryo-EM structure of the human inward-rectifier potassium 7.1 channel (Kir7.1) extended state

Method: ELECTRON MICROSCOPY D_max: 124.0 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9pr5
deposition_date	2025-07-23
title	Cryo-EM structure of the human inward-rectifier potassium 7.1 channel (Kir7.1) extended state
keywords	;inwardly rectifying potassium channel Kir7.1, KCNJ13, electrophysiology, ion channels, steroids, steroid enantiomers, MEMBRANE PROTEIN ;; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	38.51 Å
rg_electron	38.06 Å
i0	269419000.00
molecular_weight	137630.0 kDa
excluded_volume	173930 Å³
envelope_volume	240920 Å³
shell_volume	53459 Å³
envelope_diameter	125.1 Å
shell_rg	43.52 Å
envelope_rg	37.57 Å
shape_rg	38.13 Å
total_rg	38.18 Å
total_atoms	19212
n_residues	1180
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	124.0 Å
rg_real	38.52 Å
rg_real_error	0.93 Å
i0_real	2.6940e+08
i0_real_error	4.1460e+06
rg_reciprocal	38.52 Å
i0_reciprocal	269400000.0000
total_estimate	0.8896
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	42.4 Å
skewness	0.316
kurtosis	-0.547
angular_range	— – 0.2050 Å⁻¹
current_alpha	0.0000
highest_alpha	73050000.0000
n_real_points	42
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.917; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.997; Smooth: 0.812

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Inward rectifier potassium channel 13
formula_weight	40569.5 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,B,C,D
atom_count	19212

MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFPLTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFASLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 non-polymer

description	;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate ;
formula_weight	746.6 kDa
src_method	syn
entity_count	4

Entity 3 non-polymer

description	CHOLESTEROL
formula_weight	386.7 kDa
src_method	syn
entity_count	4

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.300 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.30 Å
resolution_method	—
num_particles	109323

fit	/app/data/saxs_computation/pr/9pr5/9pr5.fit
pddf	/app/data/pr_computation/pr/9pr5/9pr5.pr.out
profile	/app/data/saxs_computation/pr/9pr5/9pr5.dat

Cryo-EM structure of the human inward-rectifier potassium 7.1 channel (Kir7.1) extended state

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D