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9pw6

Myeloid cell leukemia-1 (Mcl-1) complexed with compound 8

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Induced myeloid leukemia cell differentiation protein Mcl-1

Homo sapiens

UniProt Q07820

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 ;7-[(4R,5S,6P)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-1-(2-methoxyethyl)-5-methyl-1H-indole-2-carboxylic acid ; × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 ;7-[(4R,5S,6P)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-1-(2-methoxyethyl)-5-methyl-1H-indole-2-carboxylic acid ; × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2mhs 3wix 3wix 3wix 3wix 3wiy 3wiy 3wiy 3wiy 3wiy 3wiy 4hw2

151 assemblies; showing the first 12

Homodimer
3mk8 4wmr 4wmr 5vkc 6oqb 6oqd 6ud2 6udi 6udt 6udu 6udv 8x62

12 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2kbw 2nl9 2nl9 2nl9 2nla 2pqk 2pqk 2pqk 2pqk 2pqk 2pqk 3d7v

123 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MCL1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–152； UniProt 170–321 Author chain B； PDBConstruct 1–152； UniProt 170–321

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9pw6
Deposition date deposition_date2025-08-04
Last revision last_revision2025-09-17
Structure title titleMyeloid cell leukemia-1 (Mcl-1) complexed with compound 8
Keywords keywordsMcl-1, cancer, drug discovery, APOPTOSIS; APOPTOSIS
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9pw6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9pw6__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9pw6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.15 Å
Rg (electron density)14.71 Å
Total Rg15.90 Å
Atom count1256
Residues150
Excluded volume22142 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9pw6__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9pw6__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)