Entity 1
polymer
| description | Isoform 2B of GTPase KRas |
| formula_weight | 21401.0 kDa |
| ec_number | 3.6.5.2 |
| mutation | G12C variant |
| src_method | man |
| entity_count | 2 |
Polymer
| type | polypeptide(L) |
| strand_id | A,B |
| atom_count | 5943 |
MHHHHHHGENLYFQGSTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKGNS
Source
| organism | Homo sapiens |
| common_name | human |
| ncbi_taxonomy_id | 9606 |
| host_organism | Escherichia coli |
Entity 2
non-polymer
| description | GUANOSINE-5'-DIPHOSPHATE |
| formula_weight | 443.2 kDa |
| src_method | syn |
| entity_count | 2 |
Entity 3
non-polymer
| description | MAGNESIUM ION |
| formula_weight | 24.3 kDa |
| src_method | syn |
| entity_count | 2 |
Entity 4
non-polymer
| description | DIMETHYL SULFOXIDE |
| formula_weight | 78.1 kDa |
| src_method | syn |
| entity_count | 4 |
Entity 5
non-polymer
| description | 1,2-ETHANEDIOL |
| formula_weight | 62.1 kDa |
| src_method | syn |
| entity_count | 9 |
Entity 6
non-polymer
| description | ;1-{(3S)-4-[(7M)-7-[6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl]-6-chloro-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}quinazolin-4-yl]-3-methylpiperazin-1-yl}propan-1-one
; |
| formula_weight | 624.1 kDa |
| src_method | syn |
| entity_count | 2 |
Entity 7
non-polymer
| description | DI(HYDROXYETHYL)ETHER |
| formula_weight | 106.1 kDa |
| src_method | syn |
| entity_count | 1 |
Entity 8
water
| description | water |
| formula_weight | 18.0 kDa |
| src_method | nat |
| entity_count | 177 |
