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9q73

Crystal structure of T. brucei EIF4E5 in complex with EIF4G1 peptide

Method: X-RAY DIFFRACTION D_max: 60.8 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9q73
deposition_date	2025-08-22
last_revision	2026-01-21
title	Crystal structure of T. brucei EIF4E5 in complex with EIF4G1 peptide
keywords	TRANSLATION INITIATION FACTOR, EIF4E FAMILY, EIF4E5, EIF4G1, TRANSLATION; TRANSLATION
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	18.31 Å
rg_electron	17.02 Å
i0	11168000.00
molecular_weight	25429.0 kDa
excluded_volume	32082 Å³
envelope_volume	36292 Å³
shell_volume	17709 Å³
envelope_diameter	61.7 Å
shell_rg	23.38 Å
envelope_rg	17.30 Å
shape_rg	16.99 Å
total_rg	18.14 Å
total_atoms	1790
n_residues	226
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	60.8 Å
rg_real	18.18 Å
rg_real_error	0.30 Å
i0_real	1.1170e+07
i0_real_error	1.2150e+05
rg_reciprocal	18.20 Å
i0_reciprocal	11170000.0000
total_estimate	0.8702
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	25.5 Å
skewness	0.105
kurtosis	-0.346
angular_range	— – 0.4350 Å⁻¹
current_alpha	0.0000
highest_alpha	2549000.0000
n_real_points	75
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.771; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.994; Smooth: 1.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (6)

Entity 1 polymer

description	Eukaryotic translation initiation factor 4E type 5
formula_weight	22007.0 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	2160

MEEESHALKDPWFVSYIPQLTTEIVKNNYEGDWNLAKEALQQPLDYVRTVEEFWSTLNSLPKLHQLESSSTFVFARNNVDASYEAFPNGTRIIVDIRKAAMAEKATAVILSSVIGESVSQEVCGGKPICDVLRLSSRPNKESPELVRLEVWLSDQTYGKAVLAYVRKALNDVGMSQPHVIFGESLFEKEKKKKGK

Source

organism	Trypanosoma brucei brucei TREU927
ncbi_taxonomy_id	185431
host_organism	Escherichia coli BL21(DE3)

Entity 2 polymer

description	MIF4G domain-containing protein
formula_weight	5551.4 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

MGFTKAAMEARTYPLDMFMSVSKDAAHTPYGVLCWAVKQYVTHHHHHH

Source

organism	Trypanosoma brucei brucei TREU927
ncbi_taxonomy_id	185431
host_organism	Escherichia coli BL21(DE3)

Entity 3 non-polymer

description	1,3-PROPANDIOL
formula_weight	76.1 kDa
src_method	syn
entity_count	1

Entity 4 non-polymer

description	1-BUTANOL
formula_weight	74.1 kDa
src_method	syn
entity_count	1

Entity 5 non-polymer

description	SODIUM ION
formula_weight	23.0 kDa
src_method	nat
entity_count	1

Entity 6 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	232

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6. Citations (1)

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length_a	140.410 Å
length_b	140.410 Å
length_c	41.223 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	120.00 °
z_pdb	6

space_group	P 3 2 1
int_tables_number	150
crystal_system	—

resolution	1.660 Å
resolution_low	18.810 Å
r_factor	0.1382
r_work	0.1372
r_free	0.1569

fit	/app/data/saxs_computation/q7/9q73/9q73.fit
pddf	/app/data/pr_computation/q7/9q73/9q73.pr.out
profile	/app/data/saxs_computation/q7/9q73/9q73.dat

Crystal structure of T. brucei EIF4E5 in complex with EIF4G1 peptide

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (6)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 non-polymer

Entity 4 non-polymer

Entity 5 non-polymer

Entity 6 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)