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9qfc

Tankyrase 2 ARC4 in complex with a pyrrolone-based inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Poly [ADP-ribose] polymerase tankyrase-2

Homo sapiens

UniProt Q9H2K2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 (2~{S})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one × 1 (2~{R})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one × 1 DI(HYDROXYETHYL)ETHER × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 (2~{S})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one × 1 (2~{R})-3-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-1-(4-ethylhexyl)-2-(4-hydroxyphenyl)-4-oxidanyl-2~{H}-pyrrol-5-one × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3kr7 3kr8 3kr8 3mhj 3mhj 3mhk 3p0n 3p0n 3p0p 3p0p 3p0q 3p0q

221 assemblies; showing the first 12

Homodimer
3twq 4hki 4hki 4hkk 4hkk 4hkn 4hl5 4hlf 4hlf 4hlg 4hlg 4hlh

138 assemblies; showing the first 12

Homotetramer

None

Other homooligomers
8aly 8w2u

2 assemblies

Heteromeric or nucleic-acid complex
2y0i 3twr 3twr 3twr 3twr 3tws 3tws 3tws 3tws 3twt 3twt 3twt

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNKS2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–162； UniProt 487–647 Author chain B； PDBConstruct 2–162； UniProt 487–647

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9qfc
Deposition date deposition_date2025-03-11
Last revision last_revision2026-01-14
Structure title titleTankyrase 2 ARC4 in complex with a pyrrolone-based inhibitor
Keywords keywordsInhibitor, transferase, Tankyrase 2, TNKS2, PARP5, ARC4; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9qfc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9qfc__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9qfc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.45 Å
Rg (electron density)16.55 Å
Total Rg17.59 Å
Atom count2613
Residues162
Excluded volume23022 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9qfc__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9qfc__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)