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9qo9

Inward-occluded structure of human GABA transporter 3 bound to substrate GABA

Method: ELECTRON MICROSCOPY D_max: 82.5 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9qo9
deposition_date	2025-03-25
title	Inward-occluded structure of human GABA transporter 3 bound to substrate GABA
keywords	;Transport protein, SLC6A11, neurotransmitter/sodium symporter, Sodium- and chloride-dependent GABA transporter 3, GAT3, MEMBRANE PROTEIN ;; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	24.52 Å
rg_electron	23.41 Å
i0	48982400.00
molecular_weight	59743.0 kDa
excluded_volume	76812 Å³
envelope_volume	86696 Å³
shell_volume	30113 Å³
envelope_diameter	85.9 Å
shell_rg	31.47 Å
envelope_rg	23.85 Å
shape_rg	23.41 Å
total_rg	24.39 Å
total_atoms	4204
n_residues	527
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	82.5 Å
rg_real	24.50 Å
rg_real_error	0.52 Å
i0_real	4.8980e+07
i0_real_error	6.5340e+05
rg_reciprocal	24.51 Å
i0_reciprocal	48980000.0000
total_estimate	0.8733
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	28.8 Å
skewness	0.394
kurtosis	-0.169
angular_range	— – 0.3250 Å⁻¹
current_alpha	0.0000
highest_alpha	12380000.0000
n_real_points	64
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.794; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.984; Smooth: 0.982

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	Sodium- and chloride-dependent GABA transporter 3
formula_weight	70660.4 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	4206

MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 non-polymer

description	GAMMA-AMINO-BUTANOIC ACID
formula_weight	103.1 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	CHLORIDE ION
formula_weight	35.5 kDa
src_method	syn
entity_count	1

Entity 4 non-polymer

description	SODIUM ION
formula_weight	23.0 kDa
src_method	syn
entity_count	1

Entity 5 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	2

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.200 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.20 Å
resolution_method	—
num_particles	96516

fit	/app/data/saxs_computation/qo/9qo9/9qo9.fit
pddf	/app/data/pr_computation/qo/9qo9/9qo9.pr.out
profile	/app/data/saxs_computation/qo/9qo9/9qo9.dat