Crystal Structure of an anti-VWF CK Domain Fab in Complex with the C-Terminal CK Domain of Cynomolgus Monkey von Willebrand Factor.

entry_id	9qrv
deposition_date	2025-04-04
last_revision	2026-02-11
title	Crystal Structure of an anti-VWF CK Domain Fab in Complex with the C-Terminal CK Domain of Cynomolgus Monkey von Willebrand Factor.
keywords	von Willebrand factor, CK domain, Fab, von Willebrand disease, BLOOD CLOTTING; BLOOD CLOTTING
method	X-RAY DIFFRACTION

rg_guinier	30.11 Å
rg_electron	29.62 Å
i0	62854500.00
molecular_weight	58708.0 kDa
excluded_volume	71903 ų
envelope_volume	98169 ų
shell_volume	29390 ų
envelope_diameter	115.6 Å
shell_rg	34.66 Å
envelope_rg	30.06 Å
shape_rg	29.54 Å
total_rg	30.32 Å
total_atoms	4087
n_residues	528
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	109.6 Å
rg_real	30.37 Å
rg_real_error	1.33 Å
i0_real	6.2850e+07
i0_real_error	1.0750e+06
rg_reciprocal	30.26 Å
i0_reciprocal	62850000.0000
total_estimate	0.8248
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	31.0 Å
skewness	0.601
kurtosis	-0.015
angular_range	— – 0.2650 Å−1
current_alpha	0.0000
highest_alpha	6727000.0000
n_real_points	54
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.660; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.765; Smooth: 0.973

Unit Cell

length_a	64.976 Å
length_b	116.327 Å
length_c	252.463 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

Symmetry

space_group	C 2 2 21
int_tables_number	20
crystal_system	—

Refinement

resolution	2.500 Å
resolution_low	63.120 Å
r_factor	0.2182
r_work	0.2166
r_free	0.2489

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/qr/9qrv/pr_distribution.json
• pr_output /app/data/pr_computation/qr/9qrv/9qrv.pr.out
• pr_plot /app/data/visualization/pr_computation/qr/9qrv/9qrv_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/qr/9qrv/9qrv.dat
• saxs_fit /app/data/saxs_computation/qr/9qrv/9qrv.fit
• saxs_log /app/data/saxs_computation/qr/9qrv/9qrv.log
• saxs_plot /app/data/visualization/saxs_computation/qr/9qrv/9qrv_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/qr/9qrv/9qrv.fit
pddf	/app/data/pr_computation/qr/9qrv/9qrv.pr.out
profile	/app/data/saxs_computation/qr/9qrv/9qrv.dat