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9qxz

Structure of human NONO bound to (R)-SKBG-1 in p212121

Method: X-RAY DIFFRACTION D_max: 136.8 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9qxz
deposition_date	2025-04-16
last_revision	2025-12-17
title	Structure of human NONO bound to (R)-SKBG-1 in p212121
keywords	DBHS, NONO, RNA BINDING PROTEIN; RNA BINDING PROTEIN
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	41.77 Å
rg_electron	41.47 Å
i0	879128000.00
molecular_weight	159320.0 kDa
excluded_volume	152830 Å³
envelope_volume	310040 Å³
shell_volume	63366 Å³
envelope_diameter	145.3 Å
shell_rg	46.16 Å
envelope_rg	40.42 Å
shape_rg	41.44 Å
total_rg	41.71 Å
total_atoms	12066
n_residues	1475
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	136.8 Å
rg_real	41.69 Å
rg_real_error	1.32 Å
i0_real	8.7910e+08
i0_real_error	1.6000e+07
rg_reciprocal	41.77 Å
i0_reciprocal	879200000.0000
total_estimate	0.8931
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	46.8 Å
skewness	0.244
kurtosis	-0.454
angular_range	— – 0.1900 Å⁻¹
current_alpha	0.0000
highest_alpha	38910000.0000
n_real_points	39
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.904; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.994; Smooth: 0.901

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Non-POU domain-containing octamer-binding protein
formula_weight	29672.8 kDa
src_method	man
entity_count	6

Polymer

type	polypeptide(L)
strand_id	A,B,C,D,E,F
atom_count	12233

EGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQ

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	4-(2-chloranylethanoyl)-~{N}-[(4-methoxyphenyl)methyl]-1-(4-methoxyphenyl)sulfonyl-piperazine-2-carboxamide
formula_weight	496.0 kDa
src_method	syn
entity_count	2

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	156

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6. Citations (1)

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length_a	62.258 Å
length_b	127.098 Å
length_c	201.445 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	24

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	2.500 Å
resolution_low	19.990 Å
r_factor	0.2005
r_work	0.1977
r_free	0.2533

fit	/app/data/saxs_computation/qx/9qxz/9qxz.fit
pddf	/app/data/pr_computation/qx/9qxz/9qxz.pr.out
profile	/app/data/saxs_computation/qx/9qxz/9qxz.dat

Structure of human NONO bound to (R)-SKBG-1 in p212121

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction