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9r0u

Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Carbonic anhydrase 12

Homo sapiens

UniProt O43570

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ZINC ION × 2 3-(Cyclooctylamino)-5-ethoxy-2,6-difluoro-4-((3-hydroxypropyl)sulfonyl)benzenesulfonamide × 2 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 ZINC ION × 2 3-(Cyclooctylamino)-5-ethoxy-2,6-difluoro-4-((3-hydroxypropyl)sulfonyl)benzenesulfonamide × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4ht2 4ht2 4ht2 4ht2 4q0l 4q0l 4q0l 4q0l

8 assemblies

Homodimer
1jcz 1jd0 4kp5 4kp5 4kp8 4kp8 4q0l 4q0l 4qj0 4qj0 4qjo 4qjo

70 assemblies; showing the first 12

Homotetramer
8co3

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
6rps 6rps

2 assemblies

View Construct and Data Evidence
UniProt name CAH12_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–263； UniProt 30–291 Author chain B； PDBConstruct 2–263； UniProt 30–291 Author chain C； PDBConstruct 2–263； UniProt 30–291 Author chain D； PDBConstruct 2–263； UniProt 30–291

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9r0u
Deposition date deposition_date2025-04-24
Structure title titleThree dimensional structure of human carbonic anhydrase XII in complex with sulfonamide
Keywords keywordsCA XII, CA 12, CARBONIC ANHYDRASE XII, CARBONIC ANHYDRASE 12, LYASE; LYASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9r0u__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9r0u__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9r0u__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.41 Å
Rg (electron density)24.75 Å
Total Rg25.54 Å
Atom count4230
Residues520
Excluded volume74209 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9r0u__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9r0u__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)