SAXSdb — 9sgh

▼

1. Structure Basics

entry_id	9sgh
deposition_date	2025-08-22
last_revision	2025-10-29
title	Bimekizumab Fab in complex with human interleukin-17A
keywords	Therapeutic antibody, CYTOKINE; CYTOKINE
method	X-RAY DIFFRACTION

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	41.84 Å
rg_electron	42.52 Å
i0	223621000.00
molecular_weight	118840.0 kDa
excluded_volume	147610 Å³
envelope_volume	204040 Å³
shell_volume	44442 Å³
envelope_diameter	161.7 Å
shell_rg	41.72 Å
envelope_rg	42.07 Å
shape_rg	42.49 Å
total_rg	42.57 Å
total_atoms	8352
n_residues	1071
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	152.0 Å
rg_real	42.34 Å
rg_real_error	1.59 Å
i0_real	2.2360e+08
i0_real_error	4.4260e+06
rg_reciprocal	41.85 Å
i0_reciprocal	223500000.0000
total_estimate	0.8009
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	40.0 Å
skewness	0.657
kurtosis	-0.070
angular_range	— – 0.1900 Å⁻¹
current_alpha	0.0000
highest_alpha	14730000.0000
n_real_points	39
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.621; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.774; Smooth: 0.772

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (6)

Entity 1 polymer

description	Bimekizumab Fab heavy-chain
formula_weight	25006.0 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,H
atom_count	8435

EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYNMAWVRQAPGKGLEWVATITYEGRNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASPPQYYEGSIYRLWFAHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Cricetulus griseus

Entity 2 polymer

description	Bimekizumab Fab light-chain
formula_weight	23532.1 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	B,L

AIQLTQSPSSLSASVGDRVTITCRADESVRTLMHWYQQKPGKAPKLLIYLVSNSEIGVPDRFSGSGSGTDFRLTISSLQPEDFATYYCQQTWSDPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Cricetulus griseus

Entity 3 polymer

description	Interleukin-17A
formula_weight	14119.9 kDa
mutation	C129S
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	I,J

PNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHSPNSFRLEKILVSVGCTCVTPIVHHVA

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli BL21(DE3)

Entity 4 non-polymer

description	ZINC ION
formula_weight	65.4 kDa
src_method	syn
entity_count	6

Entity 5 non-polymer

description	PHOSPHATE ION
formula_weight	95.0 kDa
src_method	nat
entity_count	1

Entity 6 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	71

▶

6. Citations (1)

▶

length_a	117.562 Å
length_b	148.492 Å
length_c	92.755 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 21 21 2
int_tables_number	18
crystal_system	—

resolution	2.661 Å
resolution_low	47.090 Å
r_factor	0.2228
r_work	0.2212
r_free	0.2531

fit	/app/data/saxs_computation/sg/9sgh/9sgh.fit
pddf	/app/data/pr_computation/sg/9sgh/9sgh.pr.out
profile	/app/data/saxs_computation/sg/9sgh/9sgh.dat

Bimekizumab Fab in complex with human interleukin-17A

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (6)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 non-polymer

Entity 5 non-polymer

Entity 6 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)