← Back to search

9t6k

Crystal structure of wild-type c-MET bound by glumetinib.

Method: X-RAY DIFFRACTION D_max: 65.3 Å Quality: GOOD

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	9t6k
deposition_date	2025-11-07
title	Crystal structure of wild-type c-MET bound by glumetinib.
keywords	Kinase, c-met, drug discovery, cancer, NSCLC, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	20.43 Å
rg_electron	19.61 Å
i0	35316400.00
molecular_weight	31044.0 kDa
excluded_volume	30244 Å³
envelope_volume	49385 Å³
shell_volume	20914 Å³
envelope_diameter	67.5 Å
shell_rg	26.22 Å
envelope_rg	20.07 Å
shape_rg	19.61 Å
total_rg	20.31 Å
total_atoms	2352
n_residues	290
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	65.3 Å
rg_real	20.38 Å
rg_real_error	0.37 Å
i0_real	3.5320e+07
i0_real_error	4.4910e+05
rg_reciprocal	20.39 Å
i0_reciprocal	35320000.0000
total_estimate	0.8151
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	24.3 Å
skewness	0.317
kurtosis	-0.310
angular_range	— – 0.3900 Å⁻¹
current_alpha	0.0000
highest_alpha	8587000.0000
n_real_points	71
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.865; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.000

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (5)

Entity 1 polymer

description	Hepatocyte growth factor receptor
formula_weight	33471.9 kDa
ec_number	2.7.10.1
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	2700

GHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 non-polymer

description	Glumetinib
formula_weight	459.5 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	POLYETHYLENE GLYCOL (N=34)
formula_weight	1529.8 kDa
src_method	syn
entity_count	2

Entity 4 non-polymer

description	DI(HYDROXYETHYL)ETHER
formula_weight	106.1 kDa
src_method	syn
entity_count	1

Entity 5 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	324

▶

6. Citations (1)

▶

length_a	37.958 Å
length_b	42.719 Å
length_c	85.287 Å
angle_alpha	90.00 °
angle_beta	92.50 °
angle_gamma	90.00 °
z_pdb	2

space_group	P 1 21 1
int_tables_number	4
crystal_system	—

resolution	1.133 Å
resolution_low	42.600 Å
r_factor	0.1827
r_work	0.1820
r_free	0.1966

fit	/app/data/saxs_computation/t6/9t6k/9t6k.fit
pddf	/app/data/pr_computation/t6/9t6k/9t6k.pr.out
profile	/app/data/saxs_computation/t6/9t6k/9t6k.dat