Entity 1
polymer
| description | Isoform 2B of GTPase KRas |
| formula_weight | 21589.2 kDa |
| ec_number | 3.6.5.2 |
| mutation | G12D,Q99L |
| src_method | man |
| entity_count | 2 |
Polymer
| type | polypeptide(L) |
| strand_id | A,B |
| atom_count | 3084 |
MGSSHHHHHHSSGENLYFQGMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYRELIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEK
Source
| organism | Homo sapiens |
| common_name | human |
| ncbi_taxonomy_id | 9606 |
| host_organism | Escherichia coli BL21(DE3) |
Entity 2
non-polymer
| description | ;4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol
; |
| formula_weight | 600.6 kDa |
| src_method | nat |
| entity_count | 2 |
Entity 3
non-polymer
| description | MAGNESIUM ION |
| formula_weight | 24.3 kDa |
| src_method | syn |
| entity_count | 2 |
Entity 4
non-polymer
| description | GUANOSINE-5'-DIPHOSPHATE |
| formula_weight | 443.2 kDa |
| src_method | syn |
| entity_count | 2 |
Entity 5
non-polymer
| description | GLYCEROL |
| formula_weight | 92.1 kDa |
| src_method | syn |
| entity_count | 3 |
Entity 6
non-polymer
| description | 1,2-ETHANEDIOL |
| formula_weight | 62.1 kDa |
| src_method | syn |
| entity_count | 1 |
Entity 7
water
| description | water |
| formula_weight | 18.0 kDa |
| src_method | nat |
| entity_count | 228 |
