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9unx

Cryo-EM structure of human OAT1 in complex with olmesartan and bromide ion.

Method: ELECTRON MICROSCOPY D_max: 93.5 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9unx
deposition_date	2025-04-24
title	Cryo-EM structure of human OAT1 in complex with olmesartan and bromide ion.
keywords	drug-drug interaction, transporter, substrate, organic anion., MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	25.70 Å
rg_electron	24.83 Å
i0	40372800.00
molecular_weight	51929.0 kDa
excluded_volume	66143 Å³
envelope_volume	80250 Å³
shell_volume	27704 Å³
envelope_diameter	97.4 Å
shell_rg	31.38 Å
envelope_rg	25.33 Å
shape_rg	24.83 Å
total_rg	25.57 Å
total_atoms	3647
n_residues	467
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	93.5 Å
rg_real	25.83 Å
rg_real_error	0.96 Å
i0_real	4.0370e+07
i0_real_error	6.7960e+05
rg_reciprocal	25.79 Å
i0_reciprocal	40370000.0000
total_estimate	0.8351
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	27.2 Å
skewness	0.564
kurtosis	0.089
angular_range	— – 0.3100 Å⁻¹
current_alpha	0.0000
highest_alpha	8944000.0000
n_real_points	63
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.662; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.877; Smooth: 0.989

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Solute carrier family 22 member 6
formula_weight	61869.0 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3647

MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 non-polymer

description	BROMIDE ION
formula_weight	79.9 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	Olmesartan
formula_weight	446.5 kDa
src_method	syn
entity_count	1

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.450 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.45 Å
resolution_method	—
num_particles	118678

fit	/app/data/saxs_computation/un/9unx/9unx.fit
pddf	/app/data/pr_computation/un/9unx/9unx.pr.out
profile	/app/data/saxs_computation/un/9unx/9unx.dat

Cryo-EM structure of human OAT1 in complex with olmesartan and bromide ion.

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D