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9uza

Crystal structure of Crimean-Congo hemorrhagic fever virus cap-snatching endonuclease

Method: X-RAY DIFFRACTION D_max: 147.6 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9uza
deposition_date	2025-05-16
title	Crystal structure of Crimean-Congo hemorrhagic fever virus cap-snatching endonuclease
keywords	cap-snatching endonuclease, HYDROLASE; HYDROLASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	41.33 Å
rg_electron	41.18 Å
i0	346707000.00
molecular_weight	151990.0 kDa
excluded_volume	190370 Å³
envelope_volume	264530 Å³
shell_volume	56078 Å³
envelope_diameter	156.5 Å
shell_rg	44.32 Å
envelope_rg	40.33 Å
shape_rg	41.15 Å
total_rg	41.46 Å
total_atoms	10709
n_residues	1362
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	147.6 Å
rg_real	41.51 Å
rg_real_error	1.68 Å
i0_real	3.4670e+08
i0_real_error	6.9100e+06
rg_reciprocal	41.33 Å
i0_reciprocal	346600000.0000
total_estimate	0.8366
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	46.6 Å
skewness	0.557
kurtosis	0.144
angular_range	— – 0.1900 Å⁻¹
current_alpha	0.0000
highest_alpha	22680000.0000
n_real_points	39
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.692; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.993; Smooth: 0.804

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	RNA-directed RNA polymerase L
formula_weight	36555.4 kDa
ec_number	2.7.7.48,3.4.19.12
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	10709

GPLGSEPIAIICDGIEGNMKQLFSVLPPDCARECEVLFDDIRNSPTHSTAWKHALRLKGTAYEGLFANCYGWQYIPEDIKPSLTMLIQTLFPDKFEDFLDRTQLHPEFRDLTPDFSLTQKVHFKRNQIPSVENVQISIDATLPESVEAVPVTERKMFPLPETPLNEVHSIERIMENFTRLMHGGKPLATKKDEDLTEQDSQQNAIEHESSSISAFKDYGERGIVEGNHMRFSEEDQLETRQLLLVEVGFQTDIDGKIRTDHKKWKDILKLLELLGIKCSFVACADCSSTPPDRWWITEDRVRILKNSVSFLFNKLSRNS

Source

organism	Orthonairovirus haemorrhagiae
ncbi_taxonomy_id	3052518
host_organism	Escherichia coli BL21(DE3)

Entity 2 polymer

description	mAb G5 Fab heavy chain
formula_weight	24788.8 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	H,C

EVMLVESGAELVRPGALVDLSCKASGFNIKDYYIHWVKQRPEQGLEWIGWIDPKNVNTIYDPKFQGKATITADTSSNTAYLRLSSLTSEDTAVYYCVRDVNYLDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHHHHHH

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Homo sapiens

Entity 3 polymer

description	mAb G5 Fab light chain
formula_weight	24058.9 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	L,D

DIKMTQSPLSLPVSLGDQASISCRSSQSLVHSNGHTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGIYFCSQSTHVPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Homo sapiens

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6. Citations (1)

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length_a	98.767 Å
length_b	99.779 Å
length_c	180.419 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	3.050 Å
resolution_low	29.110 Å
r_factor	0.2291
r_work	0.2255
r_free	0.2950

fit	/app/data/saxs_computation/uz/9uza/9uza.fit
pddf	/app/data/pr_computation/uz/9uza/9uza.pr.out
profile	/app/data/saxs_computation/uz/9uza/9uza.dat

Crystal structure of Crimean-Congo hemorrhagic fever virus cap-snatching endonuclease

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)