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9v2u

Human claudin 18.2 in complex with the Fab fragment of Osemitamab (TST001)

Method: ELECTRON MICROSCOPY D_max: 125.2 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9v2u
deposition_date	2025-05-20
title	Human claudin 18.2 in complex with the Fab fragment of Osemitamab (TST001)
keywords	;CLDN18.2, tight junction protein, therapeutic antibody, gastric cancer, MEMBRANE PROTEIN/IMMUNE SYSTEM, MEMBRANE PROTEIN-IMMUNE SYSTEM complex ;; MEMBRANE PROTEIN/IMMUNE SYSTEM
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	33.65 Å
rg_electron	34.84 Å
i0	61196700.00
molecular_weight	62330.0 kDa
excluded_volume	78236 Å³
envelope_volume	111800 Å³
shell_volume	31000 Å³
envelope_diameter	135.9 Å
shell_rg	35.72 Å
envelope_rg	34.96 Å
shape_rg	34.71 Å
total_rg	35.34 Å
total_atoms	4380
n_residues	577
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	125.2 Å
rg_real	34.20 Å
rg_real_error	1.65 Å
i0_real	6.1200e+07
i0_real_error	1.0800e+06
rg_reciprocal	33.85 Å
i0_reciprocal	61180000.0000
total_estimate	0.7461
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	34.6 Å
skewness	0.807
kurtosis	0.317
angular_range	— – 0.2350 Å⁻¹
current_alpha	0.0000
highest_alpha	6479000.0000
n_real_points	48
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.528; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.382; Smooth: 0.728

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Isoform A2 of Claudin-18
formula_weight	22236.3 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	4380

MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAAAA

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Komagataella pastoris

Entity 2 polymer

description	Fab of Osemitamab (TST001) - Heavy chain
formula_weight	27096.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	H

QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYNMNWVRQAPGQGLEWMGNIDPYYGGTSYNQKFKGRVTMTIDKSTSTVYMELSSLRSEDTAVYYCARMYHGNAFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCAAAENLYFQGDYKDDDDKHHHHHHHHHH

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Escherichia coli

Entity 3 polymer

description	Fab of Osemitamab (TST001) - Light chain
formula_weight	24122.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	L

DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNLKNYLTWYQQKPGQPPKLLIYWASTRKSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Source

organism	Mus musculus
ncbi_taxonomy_id	10090
host_organism	Escherichia coli

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.80 Å
resolution_method	—
num_particles	73763

fit	/app/data/saxs_computation/v2/9v2u/9v2u.fit
pddf	/app/data/pr_computation/v2/9v2u/9v2u.pr.out
profile	/app/data/saxs_computation/v2/9v2u/9v2u.dat

Human claudin 18.2 in complex with the Fab fragment of Osemitamab (TST001)

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)