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9vmb

The X-RAY co-crystal structure of human FGFR3 and Compound 10t

Method: X-RAY DIFFRACTION D_max: 112.1 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9vmb
deposition_date	2025-06-27
last_revision	2026-05-06
title	The X-RAY co-crystal structure of human FGFR3 and Compound 10t
keywords	FGFR3, TRANSFERASE; TRANSFERASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	35.60 Å
rg_electron	35.00 Å
i0	511771000.00
molecular_weight	121860.0 kDa
excluded_volume	117700 Å³
envelope_volume	216200 Å³
shell_volume	50592 Å³
envelope_diameter	123.2 Å
shell_rg	42.37 Å
envelope_rg	34.31 Å
shape_rg	34.99 Å
total_rg	35.39 Å
total_atoms	9203
n_residues	1141
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	112.1 Å
rg_real	35.43 Å
rg_real_error	0.65 Å
i0_real	5.1180e+08
i0_real_error	7.9810e+06
rg_reciprocal	35.54 Å
i0_reciprocal	511800000.0000
total_estimate	0.9051
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	48.4 Å
skewness	0.091
kurtosis	-0.596
angular_range	— – 0.2200 Å⁻¹
current_alpha	0.0000
highest_alpha	69020000.0000
n_real_points	45
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.930; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.972

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	Fibroblast growth factor receptor 3
formula_weight	32936.1 kDa
ec_number	2.7.10.1
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,B,C,D
atom_count	9909

GPSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRSGEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	~{N}-[1-methyl-3-[2-[[3-methyl-1-(2-morpholin-4-ylethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]indol-6-yl]propanamide
formula_weight	488.6 kDa
src_method	nat
entity_count	4

Entity 3 non-polymer

description	MAGNESIUM ION
formula_weight	24.3 kDa
src_method	syn
entity_count	4

Entity 4 non-polymer

description	GLYCEROL
formula_weight	92.1 kDa
src_method	syn
entity_count	3

Entity 5 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	694

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6. Citations (1)

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length_a	58.345 Å
length_b	112.843 Å
length_c	87.515 Å
angle_alpha	90.00 °
angle_beta	94.93 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 1 21 1
int_tables_number	4
crystal_system	—

resolution	1.970 Å
resolution_low	19.100 Å
r_factor	0.1897
r_work	0.1873
r_free	0.2368

fit	/app/data/saxs_computation/vm/9vmb/9vmb.fit
pddf	/app/data/pr_computation/vm/9vmb/9vmb.pr.out
profile	/app/data/saxs_computation/vm/9vmb/9vmb.dat