human CTPS1 with 2CTP and DON

Method: ELECTRON MICROSCOPY D_max: 156.9 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9vmm
deposition_date	2025-06-28
title	human CTPS1 with 2CTP and DON
keywords	CTP synthase, CTP, DON, cytosolic protein, STRUCTURAL PROTEIN; STRUCTURAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	45.78 Å
rg_electron	45.66 Å
i0	905295000.00
molecular_weight	248650.0 kDa
excluded_volume	311180 Å³
envelope_volume	413600 Å³
shell_volume	76453 Å³
envelope_diameter	156.8 Å
shell_rg	48.86 Å
envelope_rg	45.50 Å
shape_rg	45.74 Å
total_rg	45.52 Å
total_atoms	17456
n_residues	2164
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	156.9 Å
rg_real	45.75 Å
rg_real_error	1.26 Å
i0_real	9.0530e+08
i0_real_error	1.5770e+07
rg_reciprocal	45.78 Å
i0_reciprocal	905300000.0000
total_estimate	0.8705
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	60.0 Å
skewness	0.293
kurtosis	-0.348
angular_range	— – 0.1700 Å⁻¹
current_alpha	0.0000
highest_alpha	246600000.0000
n_real_points	35
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.821; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.849

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	CTP synthase 1
formula_weight	66777.3 kDa
ec_number	6.3.4.2
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,B,C,D
atom_count	17456

MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Saccharomyces cerevisiae

Entity 2 non-polymer

description	CYTIDINE-5'-TRIPHOSPHATE
formula_weight	483.2 kDa
src_method	syn
entity_count	8

Entity 3 non-polymer

description	MAGNESIUM ION
formula_weight	24.3 kDa
src_method	syn
entity_count	8

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6. Citations (1)

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resolution	3.30 Å
resolution_method	—
num_particles	989280

fit	/app/data/saxs_computation/vm/9vmm/9vmm.fit
pddf	/app/data/pr_computation/vm/9vmm/9vmm.pr.out
profile	/app/data/saxs_computation/vm/9vmm/9vmm.dat