Structure of rat TRPV1 in complex with SB-366791

Method: ELECTRON MICROSCOPY D_max: 132.8 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9w4n
deposition_date	2025-07-31
title	Structure of rat TRPV1 in complex with SB-366791
keywords	TRPV1, protein complex, TRANSPORT PROTEIN; TRANSPORT PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	44.26 Å
rg_electron	43.38 Å
i0	784091000.00
molecular_weight	248120.0 kDa
excluded_volume	317060 Å³
envelope_volume	443220 Å³
shell_volume	81522 Å³
envelope_diameter	136.3 Å
shell_rg	51.89 Å
envelope_rg	42.32 Å
shape_rg	43.41 Å
total_rg	43.67 Å
total_atoms	35124
n_residues	2148
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	132.8 Å
rg_real	43.91 Å
rg_real_error	0.81 Å
i0_real	7.8410e+08
i0_real_error	1.3080e+07
rg_reciprocal	44.26 Å
i0_reciprocal	784400000.0000
total_estimate	0.6667
solution_quality	REASONABLE a REASONABLE solution
n_peaks	0
r_peak_primary	— Å
skewness	-0.039
kurtosis	-0.522
angular_range	— – 0.1800 Å⁻¹
current_alpha	0.0000
highest_alpha	49610000.0000
n_real_points	37
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.913; Stabil: 1.000; Sysdev: 0.032; Positv: 1.000; Valcen: 0.956; Smooth: 0.870

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

Entity 1 polymer

description	Transient receptor potential cation channel subfamily V member 1
formula_weight	99514.6 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,B,C,D
atom_count	35124

DYKDDDDKWSHPQFEKGGGGSGGSAWSHPQFEKEFKGLVDMEQRASLDSEESESPPQENSCLDPPDRDPNCKPPPVKPHIFTTRSRTRLFGKGDSEEASPLDCPYEEGGLASCPIITVSSVLTIQRPGDGPASVRPSSQDSVSAGEKPPRLYDRRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLPMESTPHKCRGSACKPGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSGRVSGRNWKNFALVPLLRDASTRDRHATQQEEVQLKHYTGSLKPEDAEVFKDSMVPGEK

Source

organism	Rattus norvegicus
common_name	Norway rat
ncbi_taxonomy_id	10116
host_organism	Homo sapiens

Entity 2 non-polymer

description	(2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
formula_weight	287.7 kDa
src_method	syn
entity_count	4

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6. Citations (1)

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resolution	3.25 Å
resolution_method	—
num_particles	15491

fit	/app/data/saxs_computation/w4/9w4n/9w4n.fit
pddf	/app/data/pr_computation/w4/9w4n/9w4n.pr.out
profile	/app/data/saxs_computation/w4/9w4n/9w4n.dat