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9w6v

Crystal structure of 11betaHSD1 in complex with compound 1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

11-beta-hydroxysteroid dehydrogenase 1

Homo sapiens

UniProt P28845

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 3-(1-adamantyl)-6,7,8,9-tetrahydro-5~{H}-[1,2,4]triazolo[4,3-a]azepine × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 3-(1-adamantyl)-6,7,8,9-tetrahydro-5~{H}-[1,2,4]triazolo[4,3-a]azepine × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 2 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 3-(1-adamantyl)-6,7,8,9-tetrahydro-5~{H}-[1,2,4]triazolo[4,3-a]azepine × 2 Consistent with protein count
4 Protein homooligomer Homooligomer Protein 2 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 3-(1-adamantyl)-6,7,8,9-tetrahydro-5~{H}-[1,2,4]triazolo[4,3-a]azepine × 2 Consistent with protein count
5 Protein homooligomer Homooligomer Protein 2 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 3-(1-adamantyl)-6,7,8,9-tetrahydro-5~{H}-[1,2,4]triazolo[4,3-a]azepine × 2 Consistent with protein count
6 Protein homooligomer Homooligomer Protein 2 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 3-(1-adamantyl)-6,7,8,9-tetrahydro-5~{H}-[1,2,4]triazolo[4,3-a]azepine × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1xu7 1xu7 2bel 2bel 2ilt 2irw 2irw 2irw 2irw 2rbe 2rbe 3byz

70 assemblies; showing the first 12

Homotetramer
1xu7 1xu9 3bzu 3d5q 3frj 3pdj 3qqp 4hfr 4hx5 4hx5 4k1l 4p38

13 assemblies; showing the first 12

Other homooligomers
2ilt

1 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name DHI1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–246； UniProt 22–267 Author chain B； PDBConstruct 1–246； UniProt 22–267 Author chain C； PDBConstruct 1–246； UniProt 22–267 Author chain D； PDBConstruct 1–246； UniProt 22–267 Author chain E； PDBConstruct 1–246； UniProt 22–267 Author chain F； PDBConstruct 1–246； UniProt 22–267 Author chain G； PDBConstruct 1–246； UniProt 22–267 Author chain H； PDBConstruct 1–246； UniProt 22–267 Author chain I； PDBConstruct 1–246； UniProt 22–267 Author chain J； PDBConstruct 1–246； UniProt 22–267 Author chain K； PDBConstruct 1–246； UniProt 22–267

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9w6v
Deposition date deposition_date2025-08-05
Structure title titleCrystal structure of 11betaHSD1 in complex with compound 1
Keywords keywordsLipid metabolism, OXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9w6v__assembly_6__model_1

Assembly 6 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9w6v__assembly_6__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9w6v__assembly_6__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.61 Å
Rg (electron density)23.69 Å
Total Rg24.58 Å
Atom count3880
Residues480
Excluded volume67650 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9w6v__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 9w6v__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 9w6v__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 9w6v__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 9w6v__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 9w6v__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)