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9yp6

Structure of human VCP/p97 hexamer bound to ADP and UTE-156

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transitional endoplasmic reticulum ATPase

Homo sapiens

UniProt P55072

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 6 ADENOSINE-5'-DIPHOSPHATE × 6 N-(3-{[(6P)-2-(methanesulfonyl)-6-(1-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide × 6 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3qq7 4kdl 6g2v 6g2w 6g2x 6g2y 6g2z 6g30

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
10qq 10qr 3hu1 3hu2 3hu3 4kln 4ko8 4kod 4kod 5c18 5c19 5c1a

82 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
11ta 11ve 3ebb 3ebb 3qc8 3qq8 3qwz 3qwz 3tiw 3tiw 4kdi 4kdi

67 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TERA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–806； UniProt 1–806 Author chain B； PDBConstruct 1–806； UniProt 1–806 Author chain C； PDBConstruct 1–806； UniProt 1–806 Author chain D； PDBConstruct 1–806； UniProt 1–806 Author chain E； PDBConstruct 1–806； UniProt 1–806 Author chain F； PDBConstruct 1–806； UniProt 1–806

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9yp6
Deposition date deposition_date2025-10-13
Structure title titleStructure of human VCP/p97 hexamer bound to ADP and UTE-156
Keywords keywordsinhibitor, UTE-156, VCP, p97, covalent, hexamer, CHAPERONE; CHAPERONE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9yp6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9yp6__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9yp6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）54.09 Å
Rg (electron density)53.74 Å
Total Rg53.95 Å
Atom count34932
Residues4404
Excluded volume619730 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9yp6__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)