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9yq6

;Cryo-EM structure of the parainfluenza virus hemagglutinin-neuraminidase protein in complex with the human antibodies PIV3HN-09 and PIV3HN-13 ;

Method: ELECTRON MICROSCOPY D_max: 146.0 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9yq6
deposition_date	2025-10-15
title	;Cryo-EM structure of the parainfluenza virus hemagglutinin-neuraminidase protein in complex with the human antibodies PIV3HN-09 and PIV3HN-13 ;
keywords	antibody, viral protein, complex, ANTIVIRAL PROTEIN; ANTIVIRAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	43.41 Å
rg_electron	43.28 Å
i0	596258000.00
molecular_weight	198360.0 kDa
excluded_volume	247340 Å³
envelope_volume	329960 Å³
shell_volume	65590 Å³
envelope_diameter	155.9 Å
shell_rg	46.14 Å
envelope_rg	43.38 Å
shape_rg	43.27 Å
total_rg	43.44 Å
total_atoms	13961
n_residues	1794
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	146.0 Å
rg_real	43.52 Å
rg_real_error	1.32 Å
i0_real	5.9630e+08
i0_real_error	1.1150e+07
rg_reciprocal	43.41 Å
i0_reciprocal	596200000.0000
total_estimate	0.8605
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	52.7 Å
skewness	0.449
kurtosis	-0.026
angular_range	— – 0.1800 Å⁻¹
current_alpha	0.0000
highest_alpha	90090000.0000
n_real_points	37
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.849; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.991; Smooth: 0.644

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4. Crystallography & Experiment

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5. Entities & Polymer Info (7)

Entity 1 polymer

description	Hemagglutinin-neuraminidase
formula_weight	48941.6 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,F
atom_count	13961

QEVLPQRITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTVDGCVRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLNPRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIVNYDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLEHPINENVICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVADKGLNSIPKLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDYSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVSSVILDSQKSRVNPVITYSTATERVNELAILNRTLSAGYTTTSCITHYNKGYCFHIVEINHKSLNTFQPMLFKTEIPKSCS

Source

organism	Human respirovirus 3
ncbi_taxonomy_id	11216
host_organism	Homo sapiens

Entity 2 polymer

description	PIV3HN-13 Fab Heavy Chain
formula_weight	13090.4 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	B,G

EVQLLESGGALVQPGGSLRVSCAASGFSFSSYAMSWLRQTPGKGLEWVSAIGGSGHSTYYADSVQGRFTVSRDNSKDTLYLQMNSLRAEDTAVYYCAKFFRSDGVFHFDYWGPGNPGSPSP

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	PIV3HN-13 Fab Kappa Chain
formula_weight	12025.4 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	C,H

DIVMTQSPLSLPVTPGEPASISCRSSQSLRHSDGNNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGSDFTLKISRVEAEDVGVYYCMQALQTPTFGQGTKVEIK

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 4 polymer

description	PIV3HN-09 Fab Heavy Chain
formula_weight	13375.8 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	D,I

QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGSYYWSWIRQPPGKGLEWIGDIFTSGSTSYSPSLKSRVTISLDGSKNHFSLKLRSVSSADAAVYYCARESWEGAYLKYFDYWGQGTLVTVSS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 5 polymer

description	PIV3HN-09 Fab Kappa Chain
formula_weight	11727.1 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	E,J

EIVLTQSPATLSLSPGERATLSCRASQSVSTYLAWYQQKPGQAPRLLMYDASNRATGIPARFSGSGSGTDFTLTISSLESEDFAVYYCQQRSIRPWTFGQGTKVEIK

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 6 branched

description	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	367.3 kDa
src_method	man
entity_count	1

Entity 7 branched

description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	570.5 kDa
src_method	man
entity_count	1

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.950 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	2.95 Å
resolution_method	—
num_particles	198212

fit	/app/data/saxs_computation/yq/9yq6/9yq6.fit
pddf	/app/data/pr_computation/yq/9yq6/9yq6.pr.out
profile	/app/data/saxs_computation/yq/9yq6/9yq6.dat

;Cryo-EM structure of the parainfluenza virus hemagglutinin-neuraminidase protein in complex with the human antibodies PIV3HN-09 and PIV3HN-13 ;

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (7)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 polymer

Polymer

Source

Entity 5 polymer

Polymer

Source

Entity 6 branched

Entity 7 branched

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)