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9zfl

Structure of an Engineered Sodium/Iodide Symporter (PF-NIS)

Method: ELECTRON MICROSCOPY D_max: 81.3 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9zfl
deposition_date	2025-12-01
title	Structure of an Engineered Sodium/Iodide Symporter (PF-NIS)
keywords	NIS iodide SLC5A5 perrhenate, TRANSPORT PROTEIN; TRANSPORT PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	23.67 Å
rg_electron	22.85 Å
i0	40922300.00
molecular_weight	53973.0 kDa
excluded_volume	69396 Å³
envelope_volume	78591 Å³
shell_volume	28178 Å³
envelope_diameter	83.3 Å
shell_rg	30.60 Å
envelope_rg	23.21 Å
shape_rg	22.88 Å
total_rg	23.69 Å
total_atoms	3785
n_residues	506
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	81.3 Å
rg_real	23.61 Å
rg_real_error	0.58 Å
i0_real	4.0920e+07
i0_real_error	6.1930e+05
rg_reciprocal	23.63 Å
i0_reciprocal	40920000.0000
total_estimate	0.8687
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	27.9 Å
skewness	0.324
kurtosis	-0.237
angular_range	— – 0.3350 Å⁻¹
current_alpha	0.0000
highest_alpha	7115000.0000
n_real_points	65
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.769; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.990; Smooth: 0.991

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Sodium/iodide cotransporter
formula_weight	65308.9 kDa
mutation	N225Q, N485Q, N497Q, L253P, V254F
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3812

MEGAEAGARATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQQHSRINLMDFDPDPRSRYTFWTFIVGGTPFWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTQDSVLLGPPGATQASNGIPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTATLEESLVKGPEDIPAVTKKPPGLKPGAETHPLYLGHDVETNL

Source

organism	Rattus norvegicus
common_name	rat
ncbi_taxonomy_id	10116
host_organism	Homo sapiens

Entity 2 non-polymer

description	PERRHENATE
formula_weight	250.2 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	SODIUM ION
formula_weight	23.0 kDa
src_method	syn
entity_count	2

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	21

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.58 Å
resolution_method	—
num_particles	461777

fit	/app/data/saxs_computation/zf/9zfl/9zfl.fit
pddf	/app/data/pr_computation/zf/9zfl/9zfl.pr.out
profile	/app/data/saxs_computation/zf/9zfl/9zfl.dat